Взаимосвязь липидного спектра крови, уровня системного воспаления и массы тела у пациентов с ишемической болезнью сердца в сочетании с неалкогольной жировой болезнью печени и их динамика в условиях вторичной профилактики

Курята, А.В. and Гречаник, М.М. (2014) Взаимосвязь липидного спектра крови, уровня системного воспаления и массы тела у пациентов с ишемической болезнью сердца в сочетании с неалкогольной жировой болезнью печени и их динамика в условиях вторичной профилактики. Медичні перспективи, Т. 19 (№ 4). pp. 103-111. ISSN 2307-0404

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Abstract

The article analyzes the blood lipid spectrum, level of systemic inflammation and their dynamics depending on body mass index in patients with coronary heart disease (CHD) in combination with nonalcoholic fatty liver disease (NAFLD) under the of influence statin therapy. 20 men (mean age 56,4±1,44 years) with CHD and NAFLD were examined. Levels of triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP) were studied. 2 groups of patients according to BMI were distinguished: group 1 consisted of 9 (45%) patients who are overweight (BMI 25 to 30 kg/m2), group 2-8 (40%) with first degree of obesity (BMI 30 to 35). It was at found that at the initial state BMI increase at the range of 25-35 kg/m2 was not associated with a significant difference in the lipid spectrum, on the other hand on the background of treatment with pitavastatin in the dose of 2 mg for 8 weeks in patients with BMI of 25-30 kg/m2 more intensive reduction of TG (56.6%), LDL-C (31,8%), total cholesterol (22%), CRP (29.8%) and increased HDL-C (14,7%) was registered in contrast to the patients with BMI 30-35 kg/m2 – 33,7%, 22,8%, 8,8%, 10,1%, 11,9% respectively. Thus, in patients with CHD and NAFLD, pitavastatin in the dose of 2 mg has a moderate lipid-lowering effect, causes no significant increase in liver transaminases, which required dose adjustment or discontinuation of the drug.

Item Type: Article
Uncontrolled Keywords: ишемическая болезнь сердца, неалкогольная жировая болезнь печени, липидный спектр, статины; ischemic heart disease, nonalcoholic fatty liver disease, blood lipid spectrum, statins.
Subjects: Internal Medicine
Divisions: Departments > Department of Internal Medicine 2 (previously - Internal Medicine 2 and occupational diseases)
Depositing User: Елена Шрамко
Date Deposited: 13 Jun 2017 08:45
Last Modified: 13 Jun 2017 10:54
URI: http://repo.dma.dp.ua/id/eprint/1739

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