Diagnostic and prognostic role of matrix metalloproteinases in patients with chronic obstructive pulmonary disease

Basina, B.O. and Konopkina, L.І. and Kondrateva, G.V. (2017) Diagnostic and prognostic role of matrix metalloproteinases in patients with chronic obstructive pulmonary disease. The Pharma Innovation Journal, 6 (4). pp. 187-189. ISSN 2349-8242 (print), 2277- 7695 (online)


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In GOLD 2017 updated report was pointed that lung function level does not depend on patients’ categoryof future risk. That is why continuing of COPD additional risk precursors discussion is still actual.COPD is associated with increased numbers of inflammatory cells and fibroblasts and the up-regulationof proteases such as matrix metalloproteinases (MMPs) resulting in fibrosis of small airways anddestruction of the parenchyma. But these markers also constitute innovative direct or indirect targets tomodify cardiovascular tissue remodelling in atherosclerosis and heart failure. That is why it is importantto understand could really MMP-2 and MMP-9 be markers of bronchial inflammation including patientswith COPD.The aim of our work was to determine the role of initial and dynamic levels of inflammatory markersMMP-2 and MMP-9 as indicators of COPD severity, stability and treatment effectiveness.We observe patients with verified stable COPD. The levels of MMP-2 and -9 in plasma were determinedby ELISA. Investigations were done firstly on screening (visit 1). Then correction of basic antiinflammatorytreatment was done according to national and European guidelines. Repeated studies weredone on visit 2 (after 3 months of basic treatment), on visit 3 (after 6 months of basic treatment), on visit4 (after 12 months of regular basic treatment). Comparison group was patients with verified cardiacdisease. Control group was healthy people).In general levels of inflammatory markers MMP-2 and MMP-9 in COPD patients on visit 1 weresignificantly higher than in control group, but in subgroups they were almost identical. After 3 months ofadequate treatment level of MMP-2 dropped slightly, kept at this level for six months, and in one year itdecreased significantly and reached the level of the control group. On the base of regular treatment bothMMP-2 and MMP-9 decreased from visit to visit and after 12 month they have been normalized. Thisfact indicates that these markers could be parameters of effective basic treatment in patients with COPD.Increasing of such inflammatory biomarkers as MMP-2 and MMP-9 are useful index of COPD whichindicates on needing of regular basic treatment and dynamic decreasing and normalizing of MMP-2 andMMP-9 during basic treatment are signs of successful therapy during their long-term follow-up.

Item Type: Article
Uncontrolled Keywords: Prognostic role, matrix metalloproteinases, chronic obstructive pulmonary disease
Subjects: Internal Medicine
Divisions: Departments > Department of Internal Medicine 1 (formerly - Faculty Therapy and Endocrinology)
Depositing User: Елена Шрамко
Date Deposited: 26 Jun 2017 07:15
Last Modified: 10 Aug 2017 10:26
URI: http://repo.dma.dp.ua/id/eprint/1781

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