Yehudina, Y. and Syniachenko, O. and Bevzenko, T. (2018) Morphological heart changes in animals with experimental systemic lupus erythematosus. Annals of the Rheumatic Diseases, Vol.77 (2). p. 1276. ISSN 0003-4967 (print), 1468-2060 (online)
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Abstract
Background: Heart pathology in systemic lupus erythematosus (SLE) refers to the most common manifestations of the disease and largely determines its prognosis..1 2 The pathogenetic constructions of myocardium, endocardium and coronary vessel lesions remain insufficiently studied..3 4 Histological evaluation of separate cardiac structures is performed on native models of SLE in linear mice. Objectives: to study in the experiment on animals (rats) with SLE model the degree of cardiomyocytes, myocardium, endocardium, valves and cardiac vessel damage, comparing the results with thymus and spleen tissues histological data. Methods: The SLE modelling was performed in 53 white non-breeding rats (34 females and 19 males) using full Freund’s adjuvant, splenic deoxyribonucleic acid of cattle, cyclophosphamide, azid and sodium deoxyribonucleate. Cadmium sulfate, lithium oxybutyrate and ammonium molybdate were added for feeding animals. Histological heart specimen were stained with hematoxylin and eosin, altsyon blue (pH=2.6), van Gieson. PAS-reaction was applied.
| Item Type: | Article |
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| Additional Information: | Конференция: Congress of the European-League-Against-Rheumatism (EULAR); Местоположение: Amsterdam, NETHERLANDS; публ.: JUN 13-16, 2018. DOI: 10.1136/annrheumdis-2018-eular.3719 |
| Subjects: | Internal Medicine |
| Divisions: | Departments > Department of Internal Medicine 3 (formerly - hospital therapy 2) |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 24 Oct 2018 11:01 |
| Last Modified: | 24 Oct 2018 11:03 |
| URI: | http://repo.dma.dp.ua/id/eprint/3419 |
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