FibroScan and non-invasive indices for the diagnosis of non-alcoholic fatty liver disease

Stepanov, Yu.M. and Nedzvetskaya, N.V. and Yagmur, V.B. and Popok, D.V. and Shendrik, L.M. (2017) FibroScan and non-invasive indices for the diagnosis of non-alcoholic fatty liver disease. Гастроентерологія, 3. pp. 183-187. ISSN 2308-2097

статья шендрик.pdf

Download (3MB) | Preview


Background. Non-alcoholic fatty liver disease (NAFLD), an independent nosological entity, is characterized by fat accumulation in hepatocytes not associated with alcohol abuse, and includes a wide spectrum of disorders: from fatty liver, non-alcoholic steatohepatitis to fibrosis with possible outcome in liver cirrhosis. Given the prevalence of this disease, the deterioration of the quality of life of patients, increased mortality from complications, there is a growing interest in developing techniques for accurate and timely assessment of fibrosis. Objective: comparative characteristics of the results of transient elastometry (FibroScan) and non-invasive laboratory indices in the determination of fibrotic transformation of the liver in patients with non-alcoholic fatty liver disease. Materials and methods. The study included patients with NAFLD, who underwent diagnostics and treatment in the department of liver and pancreas of the SI “Institute of Gastroenterology of the NAMS of Ukraine”. Results. We have examined 42 patients with NAFLD, among which 18 (45 %) men and 24 (55 %) women. All patients underwent calculation of non-invasive markers of liver fibrosis: aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4 index, aspartate aminotransferase/alanine aminotransferase ratio, the measurement of liver stiffness using the FibroScan apparatus. Conclusions. Our results are consistent with most studies indicating that the most effective non-invasive index is APRI. The combination of transient elastography (FibroScan) and the APRI may provide a more effective approach to the diagnosis of liver fibrosis in patients with NAFLD.

Item Type: Article
Uncontrolled Keywords: неалкогольна жирова хвороба печінки; фіброз печінки; неінвазивні методи діагностики; транзієнтна еластометрія; non-alcoholic fatty liver disease; liver fibrosis; non-invasive diagnostic methods; transient elastography.
Subjects: Gastroenterology
Divisions: Faculty of Postgraduate Education > Department of Therapy, cardiology and family medicine FPE
Depositing User: Оксана Мажуга
Date Deposited: 12 Nov 2018 13:22
Last Modified: 12 Nov 2018 13:27

Actions (login required)

View Item View Item