Kolesnyk, M.Y. and Dzyak, G.V. and Nikityuk, O.V. and Kolesnyk, O.V. (2016) Carboxyterminal propeptide of procollagen type I is an independent predictor of abnormal global longitudinal strain in arterial hypertension. European Heart Journal, 37 (853). P4354. ISSN 1522-9645 (Online), 0195-668X (Print)
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Abstract
Background: Reduced global longitudinal strain (GLS) is a typical marker of left ventricle (LV) dysfunction in arterial hypertension (AH). However, abnormal GLS is nonspecific for hypertensive heart disease only. Factors which determine GLS reduction in AH are still under study. Excessive development of fibrosis is considered to be one of the key morphological features of hypertensive myocardium. Circulating carboxyterminal propeptide of procollagen type I (PICP) reflects the extent of fibrosis in the myocardium. There is a lack of studies evaluating relationship between markers of collagen turnover with myocardial deformation. The purpose of the study was to investigate the predictive role of PICP among other clinical factors for deterioration of GLS in patients with AH. Methods: The study enrolled 185 untreated hypertensive males and 40 healthy individuals (mean age 51±8 years). All participants underwent ambulatory blood pressure monitoring, laboratory testing, conventional and 2D speckle tracking echocardiography. PICP was determined by ELISA. GLS was obtained by averaging values of all 16 LVsegments from three apical planes. Abnormal GLS was defined as ≤13.5% (2 standard deviations below the mean). The logistic binary regression model was used to estimate the predictors of reduced GLS. Topic(s): Echoventricular function and myocardial diseases
| Item Type: | Article |
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| Additional Information: | ESC Congress 2016; Citation: European Heart Journal ( 2016 ) 37 ( Abstract Supplement ), 853 |
| Subjects: | Cardiology |
| Divisions: | Departments > Department of Internal Medicine 3 (formerly - hospital therapy 2) |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 03 Dec 2018 09:30 |
| Last Modified: | 03 Dec 2018 09:30 |
| URI: | http://repo.dma.dp.ua/id/eprint/3618 |
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