Перцева, Т.О. and Турлюн, Т.С. (2017) Динаміка порушення ендотеліальної функції у хворих на артеріальну гіпертензію з високим кардіоваскулярним ризиком за умов антигіпертензивної терапії. Медичні перспективи, 3. pp. 89-95. ISSN 2307-0404
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Abstract
Целью исследования было повышение эффективности ранней диагностики и оптимизации лечения эндотелиальной дисфункции у пациентов с АГ и высоким кардиоваскулярным риском. The aim of the study was to increase the efficiency of early diagnosis and optimize treatment of endothelial dysfunction in patients with AH and high cardiovascular risk. 54 patients with AH and high cardiovascular risk were followed. Of the 2a (n=29) subgroup took losartan potassium, 2b (n=25) – antihypertensive drugs without ARB II. Within 12 months in all patients, , such special clinical and laboratory parameters as: serum level of markers of endothelial dysfunction (endothelin-1, thrombomodulin and von Willebrand factor) except for general clinical examination were studied. A significant increase in the indices of ED (ET-1, von Willebrand factor, thrombomodulin) in patients with AH and high cardiovascular risk was found in comparison with the regional norm. This indicates to violation of the endothelium integrity, vasoconstriction and increased thrombus formation in the vascular wall of the isolated group of patients. According to the correlation and ROC analysis it was found that the best dynamics of ED indices in both subgroups was against the background of blood pressure stabilization, lipid spectrum decrease and abdominal obesity indicators and this is associated with the use of preparations based on ARB II in therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | артеріальна гіпертензія,цукровий діабет 2-го типу, лозартан калію, ендотелін-1, фактор Віллебранда,тромбомодулін,arterial hypertension, diabetes mellitus type 2, losartan potassium, endothelin-1, von Willebrand factor, thrombomodulin . |
| Subjects: | Internal Medicine Cardiology |
| Divisions: | Departments > Department of Internal Medicine 1 (formerly - Faculty Therapy and Endocrinology) |
| Depositing User: | Оксана Мажуга |
| Date Deposited: | 11 Jul 2019 07:18 |
| Last Modified: | 11 Jul 2019 07:18 |
| URI: | http://repo.dma.dp.ua/id/eprint/4153 |
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