Ilchenko, S. and Fialkovska, A. (2019) Clinical Features of Chronic Bronchitis and Genetic Risk Factors for Thedevelopment of Chronic Obstructive Pulmonary Disease in Adolescentsmokers. International Journal of Integrative Pediatrics and Environmental Medicine, Вип. 4. pp. 4-9. ISSN 2368-4275
|
Text
Стаття Ільченко, Фіалковська.pdf Download (334kB) | Preview |
Abstract
Introduction: Chronic bronchitis (CB) is a multifactorial disease with a complex number of internal and external etiological risk factors. One of the main risk factors for the development of CB in adolescents and chronic obstructive pulmonary disease (COPD) in adults is tobacco smoking. It is also known that an important internal risk factor for the development of СB is a genetic predisposition. Methods: We examined 40 adolescent smokers with CB, 30 never-smoker adolescents with CB, and 37 healthy adolescent smokers (control group). Each patient’s history was collected along with findings from an objective examination. Molecular genetic investigations were conducted on 30 adolescent smokers with CB and 30 healthy adolescent smokers. Calculation of the smoking index and the packs/year were made. Results: Smoking leads to the development of CB as early as adolescence and affects its course, increasing the frequency and duration of bronchitis attacks. We identified an association of the 2G/2G genotype of MMP1 gene with the development of CB in adolescent smokers. The TT genotype of CYP1A1 gene may be considered as a possible sustainability factor for the development of CB in adolescent smokers. Conclusions: The study of candidate genes for COPD in childhood and adolescence will facilitate the early detection of high-risk groups in the formation of this pathology, which will allow doctors to take the necessary preventive measures.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chronic bronchitis, COPD, tobacco smoking, adolescents |
| Subjects: | Pulmonology |
| Divisions: | Departments > Department of Children's Diseases |
| Depositing User: | Анастасия Жигар |
| Date Deposited: | 15 Aug 2019 08:02 |
| Last Modified: | 15 Aug 2019 08:02 |
| URI: | http://repo.dma.dp.ua/id/eprint/4227 |
Actions (login required)
 |
View Item |
