The effect of testosterone deficiency on the bioelectrical activity of the efferent link of the somatic reflex arc

Rodinsky, O. and Tkachenko, S. and Marazha, I. and Deforzh, G. (2020) The effect of testosterone deficiency on the bioelectrical activity of the efferent link of the somatic reflex arc. Danish Scientific Journal, Vol. 2 (№ 35). pp. 49-53. ISSN 3375-2389

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In conditions of prolonged hypoandrogenemia, changes in the bioelectric activity of the neuromuscular system were studied. The study was performed on 24 rats - males of the Wistar 5-6 months old, weighing 180-260 g. A model of the hypoandrogenic state was created by bilateral orchiectomy. After 120 days, the animals were involved in an acute experiment. Irritation (electrical impulses of a rectangular shape) was applied to the sciatic nerve, caused by the action potential was diverted from the calf muscle. We analyzed the threshold, chronaxy, latency, refractoriness (by applying double impulses), and the functional stability of the neuromuscular synapse by stimulation of the sciatic nerve with packs of 10 impulses. The muscle excitation threshold increased by 333.96 ± 2.17% with indirect and 41.67 ± 4.41% with direct irritation (p <0.01). The latent period increased by 31.93 ± 2.55%, the amplitude of the response increased by 65.44 ± 5.71%, the duration of the action potential increased by 101.99 ± 2.54% compared with the control group (p <0.001). For stimulation with paired stimuli, starting from the interval of 3 ms, a significant decrease in the rate of restoration of the amplitude of the response to the test stimulus in the group of animals with experimental hypoandrogenemia was revealed. During stimulation with bursts of impulses, starting from a frequency of 50 Hz, in animals with orchiectomy, a significant decrease in the amplitude of response caused by the tenth stimulus was observed. And at frequencies above 200 Hz, a rhythm transformation was observed. Thus, in conditions of prolonged hypoandrogenemia, a pronounced decrease in the excitability of the neuromuscular apparatus occurs, moreover due to the nervous structures, against the background of a decrease in lability and an increase in the phenomenon of homosynaptic depression in the neuromuscular synapses.

Item Type: Article
Uncontrolled Keywords: androgens, neuromuscular synapse, muscle, excitation
Subjects: Physiology
Divisions: Departments > Department of Physiology
Depositing User: Елена Шрамко
Date Deposited: 27 Jul 2021 13:38
Last Modified: 27 Jul 2021 13:50

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