Factors of resistance to progestin therapy in endometrial hyperplasia in women

Khaskhachikh, D.A. and Potapov, V.O. and Poslavska, O.V. (2023) Factors of resistance to progestin therapy in endometrial hyperplasia in women. Морфологія = Morphologia, 17 (1). pp. 56-62. ISSN 1997-9665

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Abstract

The article discusses endometrial hyperplasia (EH), a condition in which there is excessive proliferation of glandular and stromal components in the endometrium. EH is divided into atypical EH (simple or complex) and atypical EH (endometrioid intraepithelial neoplasia) based on the binary scoring system of WHO (2014). The risk of developing endometrial cancer (EC) in women with EH depends on several factors, including the type of EH, age, obesity, diabetes, and recurrent abnormal uterine bleeding. Currently, long-term cyclic progesterone therapy is an effective treatment for atypical EH, but ineffectiveness has been reported in some cases, and the reasons for this are not well understood. Objective. The purpose of the article is to investigate the possible causes of resistance of endometrial cells in its hyperplasia to progestin therapy and predict the effectiveness of therapy.

Item Type:	Article
Additional Information:	DOI: 10.26641/1997-9665.2023.1.56-62
Uncontrolled Keywords:	endometrial hyperplasia, immunohistochemistry, resistance to progesterone, receptors
Subjects:	Obstetrics Gynecology Histology
Divisions:	Departments > Department of Obstetrics and Gynecology Departments > Department of Pathological Anatomy and Forensic Medicine University periodicals > Morphology
Depositing User:	Аліна Чеботарьова
Date Deposited:	18 Oct 2023 08:16
Last Modified:	04 Apr 2024 09:51
URI:	http://repo.dma.dp.ua/id/eprint/8653

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