Molecular mechanisms of resistance of endometrial hyperplasia to progestagen therapy

Khaskhachykh, D.A. and Potapov, V. and Garagulia, I. (2023) Molecular mechanisms of resistance of endometrial hyperplasia to progestagen therapy. Грааль науки = Grail of Science (25). pp. 433-439. ISSN 2710-3056 (online)

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Abstract

The problem of resistance of atypical endometrial hyperplasia (AGE) to traditionally accepted, pathogenetically justified therapy with various types of progestins remains unsolved today. In approximately 17-20% of cases, there is a recurrence or even progression to atypical hyperplasia of the endometrium, which requires the use of surgical methods of treatment. The aim of the study was to review the literature sources to clarify the reasons for the resistance of endometrial hyperplasia without atypia to hormone therapy with different types of progestins in women with different types of estrogen and progesterone receptor expression in combination with the expression of the intercellular adhesion molecules E-cadherin and β-catenin.

Item Type:	Article
Additional Information:	https://doi.org/10.36074/grail-of-science.17.03.2023.076
Subjects:	Gynecology
Divisions:	Departments > Department of Obstetrics and Gynecology
Depositing User:	Анастасия Жигар
Date Deposited:	04 Apr 2024 11:08
Last Modified:	04 Apr 2024 11:08
URI:	http://repo.dma.dp.ua/id/eprint/8826

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