Morphological characteristics of the lungs and assess- ment of specific blood immune parameters in guinea pigs during the course of experimental pneumonia Морфологічна характеристика легень та оцінка стану окремих показників імунної системи крові морських свинок під час перебігу експериментальної пневмонії

Іванків, О.Л. and Челпанова, І.В. and Регеда, М.С. (2026) Morphological characteristics of the lungs and assess- ment of specific blood immune parameters in guinea pigs during the course of experimental pneumonia Морфологічна характеристика легень та оцінка стану окремих показників імунної системи крові морських свинок під час перебігу експериментальної пневмонії. Морфологія, 20 (1). pp. 35-40. ISSN 1997-9665

Text Morphological characteristics of the lungs and.pdf Download (213kB)

Abstract

Pneumonia is an acute inflammatory lung disease. Despite extensive experimental and clinical research, it remains a significant medical challenge. Aim. To investigate the features of morphological changes in the lungs, as well as the levels of T- and B-lymphocytes and circulating immune complexes in the blood serum of guinea pigs during the development of experimental pneumonia (EP) on days 7, 14, and 21 of the experiment. Methods. An experimental pneumonia model was established in 39 guinea pigs weighing 180–230 g. The animals were anesthetized via chloroform inhalation in a desiccator, followed by combined intranasal and inhalation administration of Staphylococcus aureus within a specifically designed chamber. Morphological examination was performed to verify pulmonary inflammation, and blood T- and B-lymphocyte counts were determined across four experimental groups. Results and conclusion. The research findings demonstrated that during the progression of experimental pneumonia (days 7, 14, and 21), there was a statistically significant decrease in cellular immunity parameters, starting from the 7th day of the study. Changes in the humoral immune status, specifically blood B-lymphocyte levels, were also observed in the experimental animals. he progression of EP is character-ized by a significant elevation of circulating immune complexes levels in the blood serum of guinea pigs on the specified experimental days; this, coupled with increased B-lymphocyte counts, suggests activation of the humoral immune response. At the observed time points (days 7, 14, and 21), experimental pneumonia is associated with a gradual decline in T-lym- phocytes, indicating potential suppression of cellular immunity alongside a statistically significant increase in B-lympho-cytes.

Item Type:	Article
Additional Information:	DOI:10.26641/1997-9665.2026.1.35-40 https://sites.google.com/dmu.edu.ua/morphology/pro-zurnal/arhiv-nomeriv/2026-vol-20-1
Uncontrolled Keywords:	experimental pneumonia, T-lymphocytes, B-lymphocytes, circulating immune complexes, immune system=експериментальна пневмонія, Т-, В-лімфоцити, циркулюючі імунні комплекси, імунна система
Subjects:	Experimental medicine Morphology
Divisions:	University periodicals > Morphology
Depositing User:	Аліна Чеботарьова
Date Deposited:	30 Jul 2026 12:52
Last Modified:	31 Jul 2026 10:20
URI:	http://repo.dma.dp.ua/id/eprint/10189

Actions (login required)

View Item