Morphologicalfeatures of mild blast-induced traumatic brain injury (literature review) Морфологічні ознаки легкої вибухо-індукованої травми головного мозку (огляд літератури)

Kozlova, Yu.V. and Kozlova, K.S. and Korzachenko, M.A. and Suloev, K.M. and Chekan, S.M. (2025) Morphologicalfeatures of mild blast-induced traumatic brain injury (literature review) Морфологічні ознаки легкої вибухо-індукованої травми головного мозку (огляд літератури). Морфологія = Morphologia, 19 (3). pp. 15-21. ISSN 1997-9665

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Abstract

The article is based on a thorough analysis of contemporary world literature devoted to the morphological study of macroscopic and microscopic markers of mild blast-induced traumatic brain injury (bTBI). The relevance of this analysis stems from the fact that blast-induced traumatic brain injury is one of the most common injuries suffered by military personnel and civilians during military operations, including while Russia's full-scale invasion of Ukraine. Mild bTBI differs from moderate and severe trauma in that there are no external signs of injury from debris or thermal factors, so it often goes undiagnosed and leads to irreversible changes that negatively affect work capacity and life quality. To create this article, an analysis of international scientific publications for the period 2006-2025 was conducted. The search for sources was performed using the keywords “blast, trauma, brain, morphology, blood-brain barrier, astrogliosis, inflammation, neurodegen- eration” in the PubMed bibliographic database, the ResearchGate scientific portal, and the ScienceDirect electronic portal. In general, mild blast-induced traumatic brain injury is diffuse damage caused by the effects of a blast wave. The main structure undergoing changes is the blood-brain barrier, damage to which consists in increased vascular permeability, causing pro- and inflammatory biologically active substances to enter the brain, contributing to the development of inflammation and astrogliosis, impaired cerebral circulation and oedema. Morphological signs of neuronal damage also indicate inflam- mation and metabolic disorders, leading to the development of neurodegeneration in the distant post-traumatic period. Axonal damage is also a characteristic feature of blast-induced traumatic brain injury.

Item Type:	Article
Additional Information:	DOI: https://doi.org/10.26641/1997-9665.2025.3.15-21 https://morphology.dmu.edu.ua/pro-zurnal/arhiv-nomeriv/2025-vol-19-3
Uncontrolled Keywords:	blast, trauma, brain, morphology, blood-brain barrier, astrogliosis, inflammation, neurodegeneration=вибух, травма, головний мозок, морфологія, гематоенцефалічний бар’єр, астрогліоз,запалення, нейродегенерація
Subjects:	Pathological anatomy Forensic medicine
Divisions:	Departments > Pathological Anatomy, Forensic Medicine and Pathological Physiology University periodicals > Morphology
Depositing User:	Аліна Чеботарьова
Date Deposited:	11 Sep 2026 08:32
Last Modified:	11 Sep 2026 08:32
URI:	http://repo.dma.dp.ua/id/eprint/10278

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