Morphology of hypothalamic nuclei under the influence of monosodium glutamate and following its withdrawal: an experimental study Морфологічні особливості ядер гіпоталамуса під впливом глутамату натрію та його відміні (експериментальне дослідження)

Vashcheniuk, M.I. and Mateshuk-Vatseba, L.R. and Stepanyuk, Y.V. and Korzhyk, O.V. and Pokotylo, O.O. and Sviatotska, L.O. and Podoliuk, M.V. (2025) Morphology of hypothalamic nuclei under the influence of monosodium glutamate and following its withdrawal: an experimental study Морфологічні особливості ядер гіпоталамуса під впливом глутамату натрію та його відміні (експериментальне дослідження). Морфологія = Morphologia, 19 (3). pp. 37-45. ISSN 1997-9665

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Abstract

The relevance of studying the effects of monosodium glutamate on hypothalamic neurons is due to its widespread use in the modern food industry and its potential impact on the regulation center of appetite and energy balance. Since glutamate is the main excitatory neurotransmitter in the brain, its excessive consumption may contribute to disturbances in neuroendocrine regulation, particularly in the hypothalamus, which is crucial for the development of obesity and related metabolic and hormonal disorders. Objective. To study the features of the structural organization of the hypothalamic nuclei under the influence of monosodium glutamate and its withdrawal in the experiment. Methods. Histological,morphometric, electron-microscopic, and statistical methods were used. Results. Changes in morphometric parameters of pyramidal and oval neurons were observed: increased cross-sectional and longitudinal diameters of perikarya and nuclei, as well as their volume. At the ultrastructural level, increased eosinophilia of the neuroplasma, vacuolization of the endoplasmic reticulum, reduction of mitochondrial cristae, increased number of lysosomes, and appearance of eosinophilic lipofuscin granules were noted.

Item Type:	Article
Additional Information:	DOI: 10.26641/1997-9665.2025.3.37-45 https://morphology.dmu.edu.ua/pro-zurnal/arhiv-nomeriv/2025-vol-19-3
Uncontrolled Keywords:	nervous system, neuron, rat, monosodium glutamate=нервова тканина, нейрон, щур, глутамат натрію
Subjects:	Histology Experimental medicine
Divisions:	University periodicals > Morphology
Depositing User:	Аліна Чеботарьова
Date Deposited:	22 Sep 2026 12:51
Last Modified:	22 Sep 2026 12:51
URI:	http://repo.dma.dp.ua/id/eprint/10289

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