Changes in systemic inflammation markers and severity of symptoms in chronic obstructive pulmonary disease patients receiving adequate basic therapy

Pertseva, T.O. and Mihailichenko, D.S. (2017) Changes in systemic inflammation markers and severity of symptoms in chronic obstructive pulmonary disease patients receiving adequate basic therapy. The Pharma Innovation Journal, 6 (2). pp. 93-96. ISSN 2349-8242 (print), 2277- 7695 (online)

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Abstract

Динамика маркеров системного воспаления и выраженности симптомов у больных хроническим обструктивным заболеванием легких на фоне адекватной базисной терапии. Целью исследования было определения выраженности системного воспаления путем определения сывороточных уровней САА и СРП у больных ХОЗЛ в стабильную фазу патологического процесса на фоне различной терапии. Материалы и методы: нами было обследовано 37 больных ХОЗЛ в стабильную фазу патологического процесса, с II-IV степенью вентиляционных нарушений. Обследование пациентов включало общие клинические методы, спирометрию, определение тяжести системного воспаления путем измерения уровней SAA и CRP в сыворотке крови. Пациенты были разделены на две подгруппы в зависимости от лечения, которое они получили. Пациенты обеих подгрупп были осмотрены дважды - в начале исследования (визит 1) и через три месяца после назначения адекватной стандартной терапии (визит 2). Many studies show that systemic inflammation marker levels should be taken into account as a key factor causing extrapulmonary complications and progression of the disease. However, assessment of systemic inflammation severity is not always used in routine medical practice to determine the severity of COPD. Aim: Determine the severity of systemic inflammation by measuring serum SAA and CRP levels during the stable phase of the disease in COPD patients who received different treatments. Materials and Methods: We have examined 37 COPD patients. Patients examination included general clinical methods, questionnaires for detecting of severity of symptoms, detecting severity of systemic inflammation by measuring serum SAA and CRP levels. Patients were divided into two subgroups depending on the treatment which they received. Patients of both subgroups were screened twice – at baseline (visit 1) and three months after assignment of adequate standard therapy (visit 2).

Item Type: Article
Uncontrolled Keywords: COPD, systemic inflammation, C-reactive protein, serum amyloid A
Subjects: Pulmonology
Divisions: Departments > Department of Internal Medicine 1 (formerly - Faculty Therapy and Endocrinology)
Depositing User: Елена Шрамко
Date Deposited: 26 Jun 2017 07:39
Last Modified: 26 Jun 2017 07:39
URI: http://repo.dma.dp.ua/id/eprint/1782

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