Molecular and cellular mechanisms of temperature reception by primary afferents

Demianenko, L.E. and Korogod, S.M. and Zholos, A.V. (2017) Molecular and cellular mechanisms of temperature reception by primary afferents. Матеріали VIІ Конгресу Українського товариства нейронаук, 7 – 11 червня 2017 р. - Київ. pp. 28-29.


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Primary afferent neurons (PANs) provide an organism interface with the environment by conveying to the CNS information about temperature, mechanical and other challenges. Temperature perception is of interest as the underlying mechanisms remain largely unknown because of restrictions of biomedical experiments. Computer models provide a complementary tool to overcome some restrictions. We combined experimental and simulation studies to disclose biophysical mechanisms, by which thermosensitive PANs convert temperatures into generator potentials and the action potential (AP) firing.

Item Type: Article
Uncontrolled Keywords: primary afferent neurons, firing patterns, temperature reception, TRPchannels, computer modeling
Subjects: Biophysics
Divisions: Other departments
Depositing User: Елена Шрамко
Date Deposited: 15 Feb 2018 09:46
Last Modified: 15 Feb 2018 09:46

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