Kuryata, O. and Sirenko, O. (2017) The Interrelation of Insulin Resistance, Serum Adiponectin Level inRheumatoid Arthritis Hypertensive Females with Subclinical Atherosclerosisand its Dynamics with the Endothelial Dysfunction Correction. Orthopaedic Surgery and Traumatology, Т. 1 (№ 5). pp. 162-173. ISSN 2573-4962
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Abstract
The study shows the results of comprehensive clinical and laboratory, instrumental, biochemical examination of 62 hypertensive females aged 45-65 years with rheumatoid arthritis, there were summarized data on the role of main and additional risk factors in the assessment of overall cardiovascular risk in these patients by studying their relationship with subclinical atherosclerosis presence. Subclinical manifestations of atherosclerosis in hypertensive patients with rheumatoid arthritis characterized by a carotid pool lesions predominance with significantly higher atherosclerotic plaques frequency definition in comparison with a group isolated rheumatoid arthritis, including unfavorable structure. However, cardiovascular risk structure by mSCORE in hypertensive patients with rheumatoid arthritis and subclinical atherosclerosis manifestations shows moderate risk dominating. The thesis shows the presence of atherosclerotic plaques in patients with hypertension combined with rheumatoid arthritis associates with endothelial dysfunction, hyperinsulinemia, age and duration of glucocorticoid therapy (based on logistic regression analysis). It was determined the role of adiponectin as a marker of atherosclerotic carotid arteries. It was estimated the effectiveness of complex therapy with oral L-Arginine solution in the normalization of endothelial dysfunction, insulin resistance reducing in hypertensive patients with rheumatoid arthritis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | hypertension, rheumatoid arthritis, subclinical atherosclerosis, Adiponectin, cardiovascular risk factors |
| Subjects: | Internal diseases |
| Divisions: | Departments > Department of Internal Medicine 2 and phthisiology |
| Depositing User: | Анастасия Жигар |
| Date Deposited: | 12 Apr 2018 11:28 |
| Last Modified: | 12 Apr 2018 11:28 |
| URI: | http://repo.dma.dp.ua/id/eprint/2608 |
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