Коваленко, О.М. and Родіонова, В.В. and Вороніна, Н.О. (2017) Особливості тромбоцитарної ланки гемостазу у хворих з хронічним обструктивним захворюванням легенів у сполученні з гіпертонічною хворобою. Медичні перспективи, Т. 22 (№3 ч.1). pp. 28-33. ISSN 2307-0404
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Abstract
The aim of the work was to study and compare the activity of thrombocytic element of hemostasis in patients with H and comorbid patients with COPD in combination with hypertension (H) in the stable course of diseases on the background of baseline therapy. A total of 53 patients were examined, of whom 21 had comorbidity of COPD and H, 22 had H and 10 almost healthy persons of the corresponding age. Indicators of blood pressure, anthropometry, spirometry with postbronchodilation test were determined. The functional activity of thrombocytes (tr) was studied using the turbidometric method by specifying the amount, degree of adhesion, spontaneous aggregation of thrombocytes and the degree, rate of aggregation of tr and the activity of Willebrand factor in stimulation of adenosine diphosphate (ADP), collagen and tr aggregation thrombin. An increase in the functional activity of tr in patients with both H and in combination of COPD and H was revealed. With comorbidity, thrombocytic activity is more pronounced, indicating additional damage to vascular endothelium and an increased risk of thrombotic and atherothrombotic complications.
| Item Type: | Article |
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| Uncontrolled Keywords: | chronic obstructive pulmonary disease, hypertension, thrombocytic activity, endothelium; хронічне обструктивне захворювання легенів, гіпертонічна хвороба, активність тромбоцитів, ендотелій. |
| Subjects: | Laboratory diagnosis Internal Medicine |
| Divisions: | Departments > Department of occupational diseases, clinical immunology and clinical pharmacology |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 20 Jul 2018 07:04 |
| Last Modified: | 20 Jul 2018 07:04 |
| URI: | http://repo.dma.dp.ua/id/eprint/3002 |
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