Залигіна, Є.В. (2017) Порівняльне вивчення токсичності густого водно-спиртового екстракту з незрілих плодів горіха волоського та препарату Альтан за повторного введення щурам. Фармакологія та лікарська токсикологія, № 6 (56). pp. 72-82. ISSN 2227-7943
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Abstract
The aim of this study was to evaluate the safety profile of thick water-alcohol extract from unripe Walnut fruit (EGVC) (Juglans regia L.) in subchronic administration and to compare it with such of Altan preparation. The subchronic toxicity of EGVC was carried out according to the «Methodological recommendations for the experimental study of the toxic effect of potential medicines». There was shown that after subchronic (within 90 days) administration of EGVC at a dose of 25 mg/kg and Altan 1 mg/kg the body weight of experimental animals remained stable, no deviations from the physiological norm were observed and also there were no significant changes in the rates of motor and research activities of animals in comparison with the initial state. In the course of the experiment, there were established that the studied drugs at subchronic intragastric administration to rats do not cause pathological changes in hematological and most biochemical indices, except for reducing glucose, total lipids and β-lipoproteins levels in the blood under influence of EGVC (unlike Altan), which, in our opinion, may be due to specific pharmacological (hypoglycemic, antiatherogenic) properties of extract and requires further study. The histological structure of the internal organs of rats treated with EGVS and Altan did not differ from such of the control group, no pathological changes were detected, which indicates the safety of the EGVS under subchronic administration. Thus, the results obtained allow considering EGVS as a safe medicine intended for long-term use.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | екстракт густий водноспиртовий з незрілих плодів горіха волоського, субхронічна токсичність, патоморфологічне дослідження; экстракт густой водно-спиртовый из незрелых плодов ореха грецкого, субхроническая токсичность, патоморфологическое исследование; the thick water-alcohol extract from unripe Walnut fruit, subchronic toxicity, pathomorphological study. |
| Subjects: | Pharmacology Experimental medicine Morphology |
| Divisions: | Departments > Department of General and Clinical Pharmacy |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 05 Dec 2018 14:30 |
| Last Modified: | 05 Dec 2018 14:30 |
| URI: | http://repo.dma.dp.ua/id/eprint/3637 |
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