Kovtunenko, Alexandr and Tymchuk, Serhij and Shportko, Bohdan (2017) Diagnostic ability of cyclin D1 and pro-apoptotic markers caspase 3 and p21 for detection of regional metastases in laryngeal cancer patients. Modern Science — Moderní věda, № 2. pp. 134-145. ISSN 2336-498X
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Abstract
Laryngeal squamous cell carcinoma has a high ability to metastasis into regional lymph nodes. The study of molecular markers of cyclin D1 showed its expression at the level of 58.3 (18.5)% (M (SD)) for the group of laryngeal squamous cell carcinoma without metastases - 48.6 (17.7)%, for the group with metastases - 66.0 (15.3)% (P <.001), the investigated level of expression of p21WAF ranged from 18% to 94% and on average amounted to 55.3 (22.1)%, for the group without metastases - 45.2 (26.0)%, for the group with metastases - 63.3 (14.3)% (P <.001). High expression of caspase 3 was detected in 40 (57.1)% and it was significantly lower (P <.001) in the group without metastases 10 (32.3)% as compared with the group of laryngeal cancer patients with regional metastases - 30 (76.9)%. In statistical analysis of the data obtained it was established that cyclin D1has the highest value of AUC (0.780), caspase-3 - somewhat lower (0.719) and p21WAF has the lowest one (0.694) (P <.01). Investigation of these markers can be used for determining the prognosis of the disease course and the choice of extent of lymph dissection. No reliable association was revealed between the expression of these markers with recurrent laryngeal squamous cell carcinoma and the degree of tumor differentiation. Additional studies of these markers can deepen our knowledge on molecular biology of the tumor and prognosis of the disease course.
| Item Type: | Article |
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| Uncontrolled Keywords: | Laryngeal squamous cell carcinoma, metastases, molecular markers, cyclin D1, caspase 3, p21WAF |
| Subjects: | Oncology Otorinolaringology |
| Divisions: | Departments > Department of Otorhinolaryngology |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 10 Dec 2018 13:44 |
| Last Modified: | 10 Dec 2018 13:44 |
| URI: | http://repo.dma.dp.ua/id/eprint/3648 |
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