Dytiatkovskyi, Volodymyr O. and Abaturov, Olexandr E. (2019) Filaggrin genotype associations with atopic march at children. Alergologia Polska – Polish Journal of Allergology, Vol. 6 (1). pp. 1-6. ISSN 2353-3854
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Abstract
Introduction: Atopic diseases affect children of all age groups, composing the atopic march (AM) – the progression of atopic inflammation from the skin to upper and lower airways, finally leading to bronchial asthma, with not enough elucidated genetic associations. Aim: We performed the first study in Ukraine of the single nucleotide polymorphism (SNP) rs7927894 of filaggrin (FLG) gene associations with atopic dermatitis (AD), seasonal allergic rhino-conjunctivitis, perennial allergic rhinitis, and bronchial asthma at children. Material and methods: Genotyping of FLG gene variants by real-time polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 119 atopic patients of the main group and 34 non-atopic patients of the control group aged 2–17 years, and IgE testing, were performed. Results: Performed correlation analysis of rs7927894 FLG variants detected significant prevalence of the C/T variant in the atopic patients compared to non-atopic (OR = 2.52; p < 0.05). T/T genotype of FLG is significantly 5-fold more strongly associated with the male gender than female (OR = 5.95; p < 0.05). The dataset obtained shows a strong association of C/T genotype of rs7927894 FLG with AD and BA incidence (OR = 3.01 and OR = 4.47; p < 0.05). Conclusions: Male atopic patients carrying the SNP rs7927894 T/T variant of the FLG gene have a 5-fold stronger significant association with atopic diseases than non-carriers of such genotype. For the first time in Ukraine there has been detected a significant association between the C/T rs7927894 genotype variant of the FLG gene in pediatric patients suffering from atopic dermatitis and bronchial asthma. A possible association (p = 0.066) between the SNP rs7927894 C/T of the FLG gene and perennial allergic rhinitis requires studies on larger patient cohorts.
| Item Type: | Article |
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| Additional Information: | https://doi.org/10.5114/pja.2019.83504 |
| Uncontrolled Keywords: | filaggrin, single nucleotide polymorphism, children, atopic march, bronchial asthma. |
| Subjects: | Pediatrics Allergology |
| Divisions: | Departments > Department of Pediatrics 1 and medical genetics (formerly - Faculty Pediatrics and Medical Genetics) |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 07 May 2019 13:33 |
| Last Modified: | 07 May 2019 13:33 |
| URI: | http://repo.dma.dp.ua/id/eprint/4051 |
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