Abaturov, Alexandr Ye. and Stepanov, Yuri M. and Nikulina, Anna A. (2019) Treatment of lactase deficiency in children’s obesity with genotype C/C 13910 of lactase gene. Wiadomości Lekarskie, tom 72 (nr 1). pp. 17-21. ISSN 0043-5147
|
Text
WL 1 2019-17-21.pdf Download (354kB) | Preview |
Abstract
Introduction: Excess lactose in the diet of modern man causes the development of not only lactase deficiency, but it can be a factor that contributes to obesity. The aim: To study associations between obesity and genotype C/C 13910 of lactase gene (LCT) in children, to investigate the effectiveness of treatment using drug exogenous lactase and a low-lactose diet. Materials and methods: genotyping of lactase gene by real-time polymerase chain reaction, determining the level of lactose maldigestion by hydrogen breath test (HBT), estimating the insulin resistance with the HOMA-IR index in 70 obese children and 40 healthy children 6 - 18 years. Obese children with genotype C/C 13910 and lactose maldigestion (n=40) were randomized in two groups: children from group I (n=20) received an exogenous lactase preparation, and children from group II (n=20) - low-lactose diet. Results: in obese children, the genotype C/C 13910 is 2 times more often than in healthy children. Obese children with genotype C/C 13910 have a significantly higher value of HBT (32.8–39.8 ppm) compared to healthy children (p<0.05), and an increased value of the HOMA-IR index. After treatment, there was a significant decrease in HBT and the HOMA-IR index in the two comparison groups. Conclusions: signs of insulin resistance are observed in children with obesity, genotype C/C 13910 and lactose maldigestion. The use of exogenous lactase in the therapy or the administration of a low-lactose diet cause approximately the same decrease in the HOMA-IR index.
| Item Type: | Article |
|---|---|
| Additional Information: | Wiad Lek 2019, 72, 1, 17-21 |
| Uncontrolled Keywords: | hydrogen breath test, genotype C/C 13910, lactose maldigestion, obesity |
| Subjects: | Pediatrics |
| Divisions: | Departments > Department of Pediatrics 1 and medical genetics (formerly - Faculty Pediatrics and Medical Genetics) |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 27 May 2019 11:30 |
| Last Modified: | 27 May 2019 11:32 |
| URI: | http://repo.dma.dp.ua/id/eprint/4090 |
Actions (login required)
 |
View Item |
