Morphological characteristics ofbrain lesions in hiv positive patients

Shostakovych-Koretskaya, L.R. and Lytvyn, K.Y. and Chykarenko, Z.O. and Usenko, T.V. and Logvinenko, V.O. (2018) Morphological characteristics ofbrain lesions in hiv positive patients. Медичні перспективи, Т. 23 (№ 1). pp. 50-55. ISSN 2307-0404

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Abstract

Currently, diseases of the central nervous systemare a common cause of death of patients with HIV infection. The article presents results of retrospective analysis ofetiotropic structure of 186 lethal cases and typical pathological changes of brain tissue of patients aged 21 to 61 yearswho had confirmed diagnosis of HIV and died of diseases associated with CNS damage in the Municipal infectioushospital in the city of Dnepr (Ukraine) in the period from 2011 to 2016. The most common causes of death in patientswith HIV infection and CNS infection were cerebral tuberculosis (75.0%) including co-infection (n = 35) andmeningoencephalitis that developed as a result of yeast fungal (15.6%). In the study of neuropathological processes inthe autopsy material of the brain tissue of patients with HIV, various multifocal and diffuse morphological changeshave been identified that can be presented in this work in the form of 4 groups: 1) Multiple nonspecific changesassociated with both direct action of HIV and co-factors: infection, inflammation, hypoxia, etc., 2) Viral-inducedvasculitis with hemorrhages, 3) Subacute aseptic encephalitis, 4) HIV-associated opportunistic infections. Generalpathomorphological changes in brain tissue are revealed that can cause similarities of clinical manifestations, cancomplicate differential diagnosis of cerebral lesions of various etiologies, and lead to a divergence of pre andpostmortal diagnoses.

Item Type:	Article
Uncontrolled Keywords:	ВІЛ-Інфекція, патологія, морфологія, головний мозок, летальність
Subjects:	HIV infection
Divisions:	Departments > Department of Infectious Diseases
Depositing User:	Ирина Медведева
Date Deposited:	12 Jun 2019 12:13
Last Modified:	12 Jun 2019 12:13
URI:	http://repo.dma.dp.ua/id/eprint/4104

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