Абатуров, О.Є. and Вакуленко, Л.І. (2019) Прогнозування хронічного перебігу пієлонефриту у дітей. Перинатология и Педиатрия, 2 (78). pp. 32-37. ISSN 2412-4613 (Online), 1992-5891 (Print)
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Abstract
Introduction. Defining factors which promote development and progressing of chronic pyelonephritis (CPN) in children is provided by timely taking preventive and adequate treatment measures, which will improve the prognosis of the disease and reduce the progression of chronic kidney disease. Purpose — defining predictive factors for development of CPN in children for carrying out early diagnostics and timely treatment. Patients and methods. The analysis of 176 chronic pyelonephritis cases in children aged from 1 to 18 years has been made. Group of comparison included 74 children with acute pyelonephritis resulted in recovery. To reveal leading predictive risk factors for development of CPN in children and to define the most informative indices, Bayes theorem and sequential Wald analysis with the assessment of informative value of signs, calculated by Kullback's measure were used (І). The sign with the coefficient 1 and more than 0.5 was considered to be informative. Results. Of high predictive informative value for the development of chronic pyelonephritis in children were 11 clinical-laboratory risk factors: abnormalities of urinary system, urodynamic disorders (vesico-urinary reflux), lingering course of the first episode of pyelonephritis or relapse during 3 months; presence of more than 5 dysembryogenic stigmas; urogenital mycoplasmosis in girls; arterial hypertension; normochromal anemia in the disease onset; neurogenic cyst / enuresis; oxalate dysmetabolic nephrоpathy with excretion of calcium oxalate more than 1,5 mg/kg/daily; hydronephrosis; concomitant chronic foci of infection. For more informative predictive signs of chronic pyelonephritis there were calculated diagnostic coefficients in their summing-up, diagnostic information can be accumulated. Inserting diagnostic symptoms obtained on patient's examination in the table, one can calculate the total of corresponding diagnostic coefficients. In the total of diagnostic coefficients equal to (+13), a probable development of chronic pyelonephritis with probability of error <5% (p<0.05) is predicted; in the total of diagnostic coefficients equal to (+20) the probability of prognosis is 99% (p<0.01). If the total of diagnostic coefficients is less than (+13) and more than (-13), the conclusion is drawn about insufficient amount of information to make a decision about a probable development of chronic pyelonephritis with the set level of error (negative response). Conclusions. Predictive table can be used for defining probability of chronic pyelonephritis development in children aged from 1 to 18 years.
| Item Type: | Article |
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| Uncontrolled Keywords: | діти, хронічний пієлонефрит, хронічна хвороба нирок, фактори ризику, прогнозування; children, chronic pyelonephritis, chronic kidney disease, risk factors, prognosis; дети, хронический пиелонефрит, хроническая болезнь почек, факторы риска, прогнозирование |
| Subjects: | Pediatrics |
| Divisions: | Departments > Department of Pediatrics 1 and medical genetics (formerly - Faculty Pediatrics and Medical Genetics) Departments > Department of Pediatrics 2 (formerly - hospital pediatrics 1) |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 29 Aug 2019 08:44 |
| Last Modified: | 30 Aug 2019 10:01 |
| URI: | http://repo.dma.dp.ua/id/eprint/4255 |
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