Kuryata, Olexandr and Lysunets, Tetiana and Karavanska, Ilona and Semenov, Viktor (2019) Duration till diagnosis and clinical profile of Sjögren’s syndrome: Data from real clinical practice in a single-center cohort. The Egyptian Rheumatologist. pp. 1110-1115. ISSN 1110-1164
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Abstract
Aim of the work: To describe the clinical features of patients with Sjögren’s syndrome (SS) in a singlecentercohort and to investigate factors that may influence duration till disease diagnosis.Patients and methods: This cross-sectional study is based on the local registry of SS patients at theRheumatology Department of Dnipropetrovsk Mechnikov Regional Hospital, Ukraine. Data from the firstadmission of 24 patients; 1 male and 23 females with a median age of 54 years (45–61 years) was analyzed.Results: In patients with primary SS (n = 19) the disease appeared at the age of 44 years (37–49 years)and the most common symptom to emerge first was ocular/oral dryness (OOD); in patients with secondarySS (n = 5) the disease mostly manifested with Raynaud’s phenomenon/rash/myalgia at the ageof 28.6 years (27–37 years). Patients with primary SS more commonly had elevated antinuclear antibody(ANA) titer, anemia, higher IgG and lower glomerular filtration rate; patients with secondary SS more frequentlyexhibited skin changes, myocarditis, heart failure and higher IgA. Median duration till diagnosiswas 8.5 years (2.8–17 years). Onset of SS with fever or Raynaud’s phenomenon/rash/myalgia shortenedthe duration till diagnosis. Presence of C-reactive protein >6 mg/dl or ANA > 1:320 may indicate primarySS in patients with symptoms of OOD. On the contrary, combination of OOD at the disease onset and positiverheumatoid factor significantly increased the duration till SS diagnosis.Conclusions: The median duration till diagnosis of SS is prolonged. Patients with symptoms of OOD at diseaseonset had significantly prolonged duration till diagnosis. 2019 Egyptian Society of Rheumatic Diseases. Publishing services provided by Elsevier B.V. This is anopen access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Sjögren’s syndrome, Clinical profile, Duration of diagnosis. |
| Subjects: | Internal Medicine |
| Divisions: | Departments > Department of Internal Medicine 2 and phthisiology |
| Depositing User: | Оксана Мажуга |
| Date Deposited: | 20 Nov 2019 08:00 |
| Last Modified: | 17 Mar 2020 08:04 |
| URI: | http://repo.dma.dp.ua/id/eprint/4531 |
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