TGF‐β1 and VCAM-1 serum concentrations as diagnostic biomarkers of diabetic kidney disease progression

Pertseva, Natalia and Borisova, Іnna (2019) TGF‐β1 and VCAM-1 serum concentrations as diagnostic biomarkers of diabetic kidney disease progression. Romanian Journal Diabetes Nutritional and Metabolism, 2. pp. 169-175.

[Romanian Journal of Diabetes Nutrition and Metabolic Diseases] TGF-1 and VCAM-1 Serum Concentrations as Diagnostic Biomarkers of Diabetic Kidne.pdf

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Aim of the study was to evaluate the significance of using transforming growth factor-beta 1 (TGF-β1) and vascular adhesion molecule -1 (VCAM-1) as prognostic markers of diabetic kidney disease progression in patients with diabetes mellitus type 1 and 2. Materials and methods. The study included 124 patients with diabetes, 66 patients with T1DM, 58 with T2DM. Patients were divided into three groups depending on the eGFR. The control group consisted of 20 healthy volunteers. All patients were comparable for age and sex. The endothelial function was determined by TGF-b1 and VCAM-1. ROC (Recognitive Operating Characteristic) – analysis was used to assess the discrimination ability (diagnostic test value) of the TGF-b1 and VCAM-1 as predictors of DKD progression. Results. Patients of all study groups had significantly higher levels of TGF-b1 and VCAM-1 (table 1) in comparison with the control group. It’s demonstrate that patients with DM have endothelial dysfunction. Diagnostic capabilities VCAM-1 and TGF-b1 for predicting DKD progression significantly exceed the diagnostic capabilities of albuminuria, which determines VCAM-1 and TGF-b1 as early markers. Conclusion. In our study it was determined that endothelial function markers – TGF-b1 and VCAM-1 can be used to predicting diabetic kidney disease progression in patients with type 1 and type 2 diabetes.

Item Type: Article
Additional Information: doi: 10.2478/rjdnmd-2019-0018
Uncontrolled Keywords: VCAM-1; TGF- β1; endothelial dysfunction; diabetes mellitus; diabetic kidney disease progression.
Subjects: Internal diseases
Divisions: Departments > Department of Endocrinology
Faculty of Postgraduate Education > Department of Medical and Social Expertise and Rehabilitation FPE
Depositing User: Оксана Мажуга
Date Deposited: 28 Nov 2019 12:54
Last Modified: 28 Nov 2019 12:54

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