Qualimetric analysis of proton pump inhibitors in Ukraine

Makarenko, O.V. and Karimova, M.M. and Masheiko, A.M. and Onul, N.M. (2019) Qualimetric analysis of proton pump inhibitors in Ukraine. Wiadomości Lekarskie, 72 (№9ч2). pp. 1769-1773. ISSN 0043-5147

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Introduction: On the pharmaceutical market of Ukraine, there are six international non-proprietary names of proton pump inhibitors (PPIs) – Omeprazole, Pantoprazole, Lansoprazole, Rabeprazole, Esomeprazole, Dexlansoprazole, which differ in a number of pharmacokinetic and pharmacodynamic parameters, safety profile, range of dosage forms and their cost. The aim: To investigate the competitiveness of proton pump inhibitors registered in Ukraine by comparing the parameters of their quality properties using the method of qualimetric analysis. Materials and methods: Qualimetric analysis is based on the deductive-axiomatic approach, which allows quantifying the qualitative properties of drugs and determining the degree of competitiveness of each of them in the pharmaceutical market of Ukraine. The qualitative properties of PPIs in terms of consumer are efficacy, safety, convenience of use and cost. The subject of the study was 133 trademarks of PPIs registered in Ukraine. Results: The highest qualimetric values were obtained by omeprazole (Kk = 0.73) and its S-isomer esomeprazole (Kk = 0.66). Pantoprazole was inferior to them to a certain extent (Kk = 0.64). Lansoprazole (Kk = 0.53), rabeprazole (Kk = 0.50) and dexlansoprazole (Kk = 0.44) had the lowest values of the quality indices. Conclusion: According to the results of the study of the PPIs' competitiveness for parameters characterizing efficacy, safety, convenience of use and cost, assessed by qualimetric analysis, it has been established that the most completely and qualitatively satisfying consumer's needs are omeprazole and its S-isomer, esomeprazole.

Item Type: Article
Uncontrolled Keywords: Competitiveness, Proton pump inhibitors, Pharmaceutical market, Qualimetric analysis, Ukraine.
Subjects: Pharmacoeconomics
Divisions: Faculty of Postgraduate Education > Department of social medicine, public health and health care management
Depositing User: Анастасия Жигар
Date Deposited: 11 Jan 2020 10:35
Last Modified: 11 Jan 2020 10:35
URI: http://repo.dma.dp.ua/id/eprint/4770

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