Молекулярно-биологические связи пародонтита и атеросклероза

Островская, С.С. and Шаторная, В.Ф. and Герасимчук, П.Г. and Леонова, Г.А. (2019) Молекулярно-биологические связи пародонтита и атеросклероза. Вісник проблем біології і медицини (1). pp. 53-56. ISSN 2077-4214

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Розглядається сучасне розуміння молекулярно-біологічних взаємодій між парадонтитами та атеросклерозом. Причини виникнення цих захворювань різноманітні і включають складну взаємодію між способом життя людини, генетичними, екологічними, соціальними й іншими факторами. Парадонтит і атеросклероз взаємодіють один з одним за допомогою системного вивільнення специфічних про- і протизапальних цитокинів, сигнальних молекул (С-реактивного білка, фактора некрозу пухлини-α, ІL-1, ІL-6 і ІL-8) і ферментів, що модулюють ініціювання і прогресування хронічної запальної реакції, зв’язаної з обома захворюваннями. Фактори ризику їхнього розвитку можуть бути знижені за рахунок регулярного стоматологічного спостереження з раннього підліткового віку. The fact that oral sepsis and the extraction of teeth are the cause of infective endocarditis has long been known, numerous data on the connection between periodontitis and atherosclerosis were obtained. The causes of periodontitis and atherosclerosis are diverse and include a complex interaction between lifestyle, genetic, environmental and other factors. Age, smoking, alcohol abuse, race/ethnicity, education and socioeconomic status, diabetes and overweight are all factors associated with both atherosclerosis and periodontitis. The role of smoking in the observed association between periodontitis and atherosclerosis is critical, and smoking cessation becomes an essential component of maintaining health and preventing many diseases, including periodontitis and atherosclerosis, while periodontitis can be an important factor in determining recurrent cardiovascular diseases in patients with myocardial infarction, and not just a marker of the effects of cigarette smoking. It has been shown that periodontitis and atherosclerosis interact with each other through the systemic release of specific pro-and antiinflammatory cytokines, small signaling molecules and enzymes that modulate the initiation and progression of the chronic inflammatory response associated with both diseases. Periodontal pathogens were identified within atherosclerotic lesions and blood clots, isolated from patients with myocardial infarction. LDL cholesterol, a persistent risk factor for atherosclerosis, is also associated with periodontitis and the statins used to treat atherosclerosis effectively prevent or reduce the development of periodontitis. Data on common factors of genetic susceptibility which is characteristic of both diseases are being accumulated. These data confirm the presence of common features in the pathogenic mechanisms involved in both inflammatory diseases. Systemic inflammation is tested by several inflammatory markers, including C-reactive protein, which is a predictor of future cardiovascular diseases, including myocardial infarction, stroke, peripheral arterial disease and sudden cardiac death. Paradontitis is similarly associated with the increase in systemic inflammatory markers except for C-reactive protein, – tumor necrosis factors α, IL-1, IL-6 and IL-8. This is accompanied by cell activation with the inclusion of cell adhesion molecules and activation of nuclear factor-κB. As a result, the interaction between endothelium, monocytes and platelets can become proatherogenic, indirectly contributing to atherosclerosis with an unfavourable outcome due to rupture of atheromatous plaque, which is observed in patients with periodontitis. Risk factors for cardiovascular diseases, especially atherosclerosis, can be reduced with the help of proper treatment of periodontitis and its effective prevention. Today, the most important is regular dental follow-up from early adolescence.

Item Type: Article
Additional Information: DOI 10.29254/2077-4214-2019-1-1-148-53-56
Uncontrolled Keywords: парадонтит, атеросклероз, фактори ризику, periodontitis, atherosclerosis, their interrelation.
Subjects: Medical Biology
Internal Medicine
General dentistry
Divisions: Departments > Department of Medical Biology, Botany and Pharmacognosy
Departments > Department of Orthopedic Dentistry
Depositing User: Оксана Мажуга
Date Deposited: 28 Jan 2020 12:43
Last Modified: 28 Jan 2020 12:43
URI: http://repo.dma.dp.ua/id/eprint/4854

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