Sirko, A. and Yovenko, I. and Zhyliuk, V. and Mosentsev, M. and Pilipenko, G. (2019) Antibacterial Therapy for Purulent-Septic Complications in Patientswith Combat Related Penetrating Craniocerebral Gunshot Wounds. Georgian Medical News=Медицинские новости Грузии, № 9 (294). pp. 10-16. ISSN 1512-0112
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Abstract
Aim - to evaluate pathogens and their susceptibility to antibiotic therapy (ABT) in combat-related penetrating craniocerebral gunshot wound (PCGW) patients and develop recommendations for treatment of post-traumatic meningoencephalitis. We conducted a prospective analysis of examination and treatment results of 121 patients who were admitted to the Public Institution, Mechnikov Dnipropetrovsk Regional Clinical Hospital, Dnipro, Ukraine, from 25 May 2014, to 31 December 2017, and were successively enrolled in the study. Intracranial purulent-septic complications were diagnosed in 14 (11.6%) patients including eight cases of isolated meningoencephalitis, three cases of meningoencephalitis combined with ventriculitis, two cases of meningoencephalitis combined with ventriculitis and subdural empyema and one case of multiple brain abscesses. In most cases of combat-related craniocerebral wounds, infections are considered nosocomial and typically related to medical procedures and devices. In most cases, the effectiveness of first-line antibiotics was low, and it was often necessary to prescribe broad-spectrum ABT, including those related to secondline antibiotics and reserve drugs, according to the World Health Organisation classification. The use of initial de-escalation of empiric ABT with the broadest-spectrum drugs, mainly as a part of combination therapy for expected gram-positive and gramnegative aerobic and anaerobic infection pathogens, is recommended.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | purulent-sertic complications, pathogens, susceptibility of pathogens, antibacterial therapy, penetrating craniocerebral wounds, combat-related gunshot wounds. |
| Subjects: | Neurosurgery |
| Divisions: | Faculty of Postgraduate Education > Department of Neurology and Neurosurgery FPE |
| Depositing User: | Анастасия Жигар |
| Date Deposited: | 07 Feb 2020 11:52 |
| Last Modified: | 07 Feb 2020 11:52 |
| URI: | http://repo.dma.dp.ua/id/eprint/4916 |
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