Kuryata, O. and Lysunets, T. and Karavanska, I. and Semenov, V. (2020) Duration till diagnosis and clinical profile of Sjögren’s syndrome: Data from real clinical practice in a single-center cohort. The Egyptian Rheumatologist, Vol.42 (Iss. 1). pp. 41-46. ISSN 1110-1164
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Abstract
Aim of the work: To describe the clinical features of patients with Sjögren’s syndrome (SS) in a singlecenter cohort and to investigate factors that may influence duration till disease diagnosis. Patients and methods: This cross-sectional study is based on the local registry of SS patients at the Rheumatology Department of Dnipropetrovsk Mechnikov Regional Hospital, Ukraine. Data from the first admission of 24 patients; 1 male and 23 females with a median age of 54 years (45–61 years) was analyzed. Results: In patients with primary SS (n = 19) the disease appeared at the age of 44 years (37–49 years) and the most common symptom to emerge first was ocular/oral dryness (OOD); in patients with secondary SS (n = 5) the disease mostly manifested with Raynaud’s phenomenon/rash/myalgia at the age of 28.6 years (27–37 years). Patients with primary SS more commonly had elevated antinuclear antibody (ANA) titer, anemia, higher IgG and lower glomerular filtration rate; patients with secondary SS more frequently exhibited skin changes, myocarditis, heart failure and higher IgA. Median duration till diagnosis was 8.5 years (2.8–17 years). Onset of SS with fever or Raynaud’s phenomenon/rash/myalgia shortened the duration till diagnosis. Presence of C-reactive protein >6 mg/dl or ANA > 1:320 may indicate primary SS in patients with symptoms of OOD. On the contrary, combination of OOD at the disease onset and positive rheumatoid factor significantly increased the duration till SS diagnosis. Conclusions: The median duration till diagnosis of SS is prolonged. Patients with symptoms of OOD at disease onset had significantly prolonged duration till diagnosis. © 2019 Egyptian Society of Rheumatic Diseases. Publishing services provided by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
| Item Type: | Article |
|---|---|
| Additional Information: | https://doi.org/10.1016/j.ejr.2019.05.003 |
| Uncontrolled Keywords: | Sjögren’s syndrome, Clinical profile, Duration of diagnosis |
| Subjects: | Internal diseases Rheumatology |
| Divisions: | Departments > Department of Internal Medicine 2 and phthisiology |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 13 Feb 2020 14:19 |
| Last Modified: | 17 Mar 2020 08:03 |
| URI: | http://repo.dma.dp.ua/id/eprint/4951 |
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