Rodinsky, Alexander and Demchenko, Helena and Kondratyeva, Helena and Vasilenko, Anatolii and Scubitskaya, Luydmila (2019) Age peculiarities of the cognitive functions of rats in terms of violations of thyroid balance. Modern Science — Moderní věda, № 2. pp. 123-134. ISSN 2336-498X
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Abstract
In experiments on animals of three age groups, the cognitive activity of the central nervous system was investigated under dysfunction of the thyroid gland. With experimental hyperthyroidism in juvenile (5-6 weeks) rats, there was an improvement in the process of formation of conditional protective reaction and anxiolytic effect in a cross-shaped elevated labyrinth, accumulation of the inhibitory neurotransmitter amino acid - GABA in the cortex of 38.5% (anxiolytic action), as well as excitatory amino acids - glutamate in the hippocampus by 45.6% (mnastic activity). In young (5-6 months) animals to a lesser extent anxiolytic effect and cognitive activity were observed. In neocortex, significant accumulation of inhibitory neurotransmitter amino acids - GABA at 49.3%, glycine by 17.5%, serotonin by 33%, total NO synthase by 59.6%. In older rats there was a pronounced inhibition of cognitive function, a decrease in the content of GABA by 46.1%, serotonin by 17.3%, NO synthase activity by 37%, and an increase in glutamate by 61.5%. The condition of hypothyroidism of the thyroid gland was accompanied by inhibition of cognitive function, to a greater extent in the old rats. In juvenile individuals, memory decline occurred on the background of increased anxiety. In young rats, inhibition of mestizal activity was accompanied by a sharp decrease in emotional and anxiety. This condition is ensured by an increase in the neocortex content of serotonin and glycine by 37.1% and 17.5%, respectively, of total NO synthase by 36.8% in this brain structure. In older animals, hypothyroidism caused an increase in glutamate levels in the cortex of 84.6% and a 109.6% hippocampus, which is possibly causative exitotoxic effect.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | experimental hyperthyroidism, hypothyroidism; ontogenesis; cognitive function; neurotransmitter amino acids. |
| Subjects: | Physiology |
| Divisions: | Departments > Department of Physiology |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 22 Apr 2020 11:39 |
| Last Modified: | 22 Apr 2020 11:39 |
| URI: | http://repo.dma.dp.ua/id/eprint/5255 |
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