Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis

Korsunskiy, Ilya and Blyuss, Oleg and Gordukova, Maria and Davydova, Natalia and Zaikin, Alexey and Zinovieva, Natalia and Zimin, Sergey and Molchanov, Robert and Salpagarova, Aminat and Eremeeva, Alina and Filipenko, Maxim and Prodeus, Andrey and Korsunskiy, Anatoliy and Hsu, Peter and Munblit, Daniel (2020) Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis. Frontiers in Immunology, Vol.11 (320). pp. 1-9. ISSN 1664-3224


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Official URL: https://www.frontiersin.org/journals/immunology


Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early detection of PID remains a challenge, particularly in older children with milder and less specific symptoms. This study aimed to assess TREC and KREC diagnostic ability in PID. Data from children assessed by clinical immunologists at Speransky Children’s Hospital, Moscow, Russia with suspected immunodeficiencies were analyzed between May 2013 and August 2016. Peripheral blood samples were sent for TREC/KREC, flow cytometry (CD3, CD4, CD8 and CD19), IgA and IgG analysis. A total of 434 children [189 healthy, 97 with group I and II PID (combined T and B cell immunodeficiencies & well-defined syndromes with immunodeficiency) and 148 group III PID (predominantly antibody deficiencies)] were included. Area under the curve (AUC) for TREC in PID groups I and II diagnosis reached 0.82 (CI = 0.75–0.90), with best model providing sensitivity of 65% and specificity of 92%. Neither TREC, nor KREC had added value in PID group III diagnosis. In this study, the predictive value of TREC and KREC in PID diagnosis was examined. We found that the TREC had some diagnostic utility for groups I and II PID. Possibly, addition of TREC measurements to existing clinical diagnostic algorithms may improve their predictive value. Further investigations on a larger cohort are needed to evaluate TREC/KREC abilities to be used as diagnostic tools on a wider scale.

Item Type: Article
Additional Information: Citation: Korsunskiy I, Blyuss O, Gordukova M, Davydova N, Zaikin A, Zinovieva N, Zimin S, Molchanov R, Salpagarova A, Eremeeva A, Filipenko M, Prodeus A, Korsunskiy A, Hsu P and Munblit D (2020) Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis. Front. Immunol. 11:320. doi: 10.3389/fimmu.2020.00320
Uncontrolled Keywords: TREC, KREC, primary immunodeficiency diseases, PID, primary immunodeficiency diseases diagnosis
Subjects: Immunology
Divisions: Departments > Department of Surgery №1
Depositing User: Елена Шрамко
Date Deposited: 23 Apr 2020 12:34
Last Modified: 23 Apr 2020 12:34
URI: http://repo.dma.dp.ua/id/eprint/5267

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