Tubulin Role in Cancer Development and Treatment

Dolhyi, V and Avierin, D and Hojouj, M and Bondarenko, I (2019) Tubulin Role in Cancer Development and Treatment. Asploro Journal of Biomedical and Clinical Case Reports, Vol. 2 (Iss. 2). pp. 15-22. ISSN 2582-0370


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This review work is done to show a significance of tubulin in cancer development. Within last decades there are a lot of studies have performed in this area. Now it is clear that there are an enormous number of functions in cell performing by microtubules, a structure unit of which is tubulin. Now it used widely as a predictive factor of tumor aggressiveness, but increasingly it becomes a target for studying and treatment elaboration, since it is wellknown that to nowadays tubulin-targeted medicines, such as taxanes or vinca-alkaloids, resistance develops rather quickly, so it consists a large problem in oncology. This work reveals basic microtubule functions, violations that it may undergo and consequences of these. Also it is described here the main modern tendencies in creation of remedy which will make it possible breakthrough treatment resistance barrier.

Item Type: Article
Additional Information: Citation: Dolhyi V, Avierin D, Hojouj M, Bondarenko I. Tubulin Role in Cancer Development and Treatment. Asp Biomed Clin Case Rep. 2019 Sept 5;2(2):15-22.
Uncontrolled Keywords: Tubulin; Cancer Development; Malignant Neoplasm; Microtubules; Centrosomes
Subjects: Oncology
Divisions: Departments > Department of Oncology and Medical Radiology
Depositing User: Елена Шрамко
Date Deposited: 29 Apr 2020 10:31
Last Modified: 29 Apr 2020 10:31
URI: http://repo.dma.dp.ua/id/eprint/5297

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