Morphological Changes in the Upper Part of Digestive Tract in a Case of Experimental Duodenogastric Reflux

Romanenko, Ye.G. and Komskyi, M.P. (2018) Morphological Changes in the Upper Part of Digestive Tract in a Case of Experimental Duodenogastric Reflux. Journal of Biomimetics, Biomaterials and Biomedical Engineering, V. 35. pp. 77-87. ISSN 2296-9845

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Abstract

Experimental reproduction of duodeno-gastric reflux was performed among Wistar line 28 rats, which were injected with 50 % solution of medical bile by intragastric way. Morphological study had been shown significant structural changes in the gingival tissues, mucous membrane of an esophagus, stomach and duodenum. In the epithelial layer of gingiva and esophagus was observed numerous infringements in a process of differentiation cells, in the stroma was shown phenomena of fibrosis in a papillary layer, microcirculation disorders. In the gastric mucosa had been found out multiple erosions, the glandular cells were increased. It was demonstrated vacuolization of the basal and thorn layers of the stomach epithelium. In the stroma defined phenomena of fibrosis and a dense lymphocyte infiltration with eosinophils. In the duodenum was determined desquamation of a glandular epithelium, superficial erosions of the villi, lympho–histio–plasmocytosis infiltration in a stroma, microvascular disorders. The given experiment demonstrates a role of functional disorders in the pathogenesis of combined pathology in the upper gastrointestinal tract.

Item Type:	Article
Additional Information:	doi:10.4028/www.scientific.net/JBBBE.35.77
Uncontrolled Keywords:	Reflux, Bile, Mucous Membrane, Gingiva, Esophagus, Stomach, Duodenum.
Subjects:	Pediatric Dentistry Morphology
Divisions:	Departments > Department of Pediatric Dentistry
Depositing User:	Анастасия Жигар
Date Deposited:	25 May 2020 11:18
Last Modified:	25 May 2020 11:18
URI:	http://repo.dma.dp.ua/id/eprint/5406

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