Immune Response in Patients with Mandible Fracture Complicated with Suppuration of a Bone Wound

Komskyi, M.P. and Romanenko, Ye.G. (2018) Immune Response in Patients with Mandible Fracture Complicated with Suppuration of a Bone Wound. Journal of Biomimetics, Biomaterials and Biomedical Engineering, V. 36. pp. 1-6. ISSN 2296-9845

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Abstract

Modern clinical observations focused on the increasing complications at the open mandible fracture, which indicated about severe immune suppression in patients with this pathology. For estimation cellular immunity in a peripheral blood there were examined 25 patients in basic group (15 men, 10 women) with mandible fracture, complicated with abscess of a bone wound; control group included 20 practically healthy persons (10 men and 10 women). To assess cellular immunity in the peripheral blood were determined: absolute number of leukocytes, relative amount of lymphocytes; phagocytic activity. Determination relative number of T–lymphocytes (phenotype CD2+, СD3+) and B – lymphocytes (phenotype СD22+) was performed by method of immunofluorescence with monoclonal antibodies. In a case of mandible fracture, complicated with abscess of bone wound and leukocytosis, in the patients were reduced parameters of cellular immunity: on 40.3% – phagocytic index, on 47.7% – phagocytic number, on 43.9% – content of CD2+– and CD3+– lymphocytes. Content of null cells was increased on 76.8 %. On the 7th day of postoperative treatment in patients from basic group was decreased level of leukocytes on 16.5%, increased level of monocytes on 28.6%, and lymphocytes – on 13.4%, which indicated about decreasing of inflammatory process and active current of reparative process. After 14 day of clinical observations, leukocytes and lymphocytes were in the normal values. It was noted increasing indicators of phagocytic activity, but number of T–lymphocytes was reduced. Content of null cells did not have significant difference from it initial level, which was before treatment. Indicators of cellular immunity demonstrated incompleteness of inflammatory process and immunosuppression activity, which was carried out two weeks after traditional treatment of the bone wound suppuration in a case of mandible fracture. This requires development of a new approach of pathogenetic therapy.

Item Type:	Article
Additional Information:	https://doi.org/10.4028/www.scientific.net/JBBBE.36.1
Uncontrolled Keywords:	fracture of jaw, infection, immunity, leukocytes, phagocytosis, T – lymphocytes, B – lymphocytes, null cells
Subjects:	Surgical Dentistry
Divisions:	Departments > Department of Pediatric Dentistry
Depositing User:	Анастасия Жигар
Date Deposited:	25 May 2020 11:54
Last Modified:	25 May 2020 11:54
URI:	http://repo.dma.dp.ua/id/eprint/5407

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