Nathan, Paul D. and Robert, Caroline and Grob, Jean Jacques and Stroyakovskiy, Daniil and Karaszewska, Boguslawa and Hauschild, Axel and Levchenko, Eugeny and Sileni, Vanna Chiarion and Schachter, Jacob and Garbe, Claus and Bondarenko, Igor and Davies, Michael A. and Ribas, Antoni and Flaherty, Keith and Burgess, Paul and Tan, Monique and Gasal, Eduard and Schadendorf, Dirk and Georgina V. (2019) Five-year analysis on the long-term effects of dabrafenib plus trametinib (D + T) in patients with BRAF V600–mutant unresectable or metastatic melanoma. Journal of Clinical Oncology, 37 (15supp). p. 9507. ISSN 1527-7755 (online, version of record) and 0732-183X (print)
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Abstract
Background: First-line treatment with D+T demonstrated prolonged progression-free survival (PFS) and overall survival (OS) in patients with BRAF V600–mutant unresectable or metastatic melanoma. With 5 years of follow-up, we report survival and describe characteristics of patients in the phase 3 COMBI-d and COMBI-v trials with long-term benefit. Methods: Pooled 5-year landmark data for patients treated with D+T in the phase 3 COMBId (NCT01584648) and COMBI-v (NCT01597908) trials were analyzed. The trials enrolled patients with previously untreated BRAF V600E/K–mutant unresectable or metastatic melanoma. Patients received D 150 mg twice daily plus T 2 mg once daily vs either D + placebo (COMBI-d) or vemurafenib (COMBI-v). The primary endpoints were PFS in COMBI-d and OS in COMBI-v. Results: The pooled population included 563 patients who received D+T (COMBI-d, n = 211; COMBI-v, n = 352).
| Item Type: | Article |
|---|---|
| Additional Information: | ARTICLE CITATION DOI: 10.1200/JCO.2019.37.15_suppl.9507 Journal of Clinical Oncology - published online before print May 26, 2019 |
| Subjects: | Oncology |
| Divisions: | Departments > Department of Oncology and Medical Radiology |
| Depositing User: | Елена Шрамко |
| Date Deposited: | 03 Jun 2020 10:53 |
| Last Modified: | 03 Jun 2020 10:57 |
| URI: | http://repo.dma.dp.ua/id/eprint/5428 |
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