Radiation-Induced Cerebro-Ophthalmic Effectsin Humans

Loganovsky, Konstantin N. and Marazziti, Donatella and Fedirko, Pavlo A. and Kuts, Kostiantyn V. and Antypchuk, Katerina Y. and Perchuk, Iryna V. and Babenko, Tetyana F. and Loganovska, Tetyana K. and Kolosynska, Olena O. and Kreinis, George Y. and Gresko, Marina V. and Masiuk, Sergii V. and Mucci, Federico and Zdorenko, Leonid L. and Della Vecchia, Alessandra and Zdanevich, Natalia A. and Garkava, Natalia A. and Dorichevska, Raisa Y. and Vasilenko, Zlata L. and Kravchenko, Victor I. and Drosdova, Nataliya V. (2020) Radiation-Induced Cerebro-Ophthalmic Effectsin Humans. Life, 10 (4) (41). pp. 1-17. ISSN 2075-1729


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Official URL: http://www.mdpi.com/journal/life


: Exposure to ionizing radiation (IR) could affect the human brain and eyes leading to both cognitive and visual impairments. The aim of this paper was to review and analyze the current literature, and to comment on the ensuing findings in the light of our personal contributions in this field. The review was carried out according to the PRISMA guidelines by searching PubMed, Scopus, Embase, PsycINFO and Google Scholar English papers published from January 2000 to January 2020. The results showed that prenatally or childhood-exposed individuals are a particular target group with a higher risk for possible radiation effects and neurodegenerative diseases. In adulthood and medical/interventional radiologists, the most frequent IR-induced ophthalmic effects include cataracts, glaucoma, optic neuropathy, retinopathy and angiopathy, sometimes associated with specific neurocognitive deficits. According to available information that eye alterations may induce or may be associated with brain dysfunctions and vice versa, we propose to label this relationship “eye-brain axis”, as well as to deepen the diagnosis of eye pathologies as early and easily obtainable markers of possible low dose IR-induced brain damage.

Item Type: Article
Additional Information: http://dx.doi.org/10.3390/life10040041 Идентификационный номер: WOS:000533885500020 Идентификатор PubMed: 32316206
Uncontrolled Keywords: ionizing radiation; brain; neurocognitive deficits; glaucoma; optic neuropathy; retinopathy; angiopathy
Subjects: Ophthalmology
Nuclear medicine
Neurological disease
Depositing User: Елена Шрамко
Date Deposited: 15 Jun 2020 08:08
Last Modified: 15 Jun 2020 08:08
URI: http://repo.dma.dp.ua/id/eprint/5434

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