The Influence of L-Carnitine in the ComplexTreatment of PatientsWith Renal DysfunctionWho Have Synchronous Chronic Coronary ArteryDisease and Prostate Adenocarcinoma

Kuruata, O. and Sirenko, O. (2019) The Influence of L-Carnitine in the ComplexTreatment of PatientsWith Renal DysfunctionWho Have Synchronous Chronic Coronary ArteryDisease and Prostate Adenocarcinoma. Turkiye Klinikleri Journal of Medical Sciences, V. 39 (No 4). pp. 381-388. ISSN 1300-0292 (print), 2146-9040 (online)

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Abstract

Objective: The aim of the study is to evaluate the effect of L-Carnitine on the dynamics ofinflammation, insulin resistance (IR), functional status of kidneys in the complex therapy of patientswith coronary heart disease (CHD) in combination with prostate adenocarcinoma and renal dysfunction.Material and Methods: Forty two men with prostate adenocarcinoma and coronary heart disease wereenrolled. The patients were randomly and blindly divided into 2 groups: Group I patients were treatedwith L-Carnitine in addition to standard treatment; Group II patients received only conventional treatment.Standard laboratory blood tests, lipid profile, glucose, renal and liver function tests, serum C-reactiveprotein (CRP), insulin, testosterone levels, echocardiographic examination were performed for allpatients at baseline and after 10 days of treatment. Results:Median level of HOMA index was 3.1 [1.9;4.8] mg/ml. Insulin resistance was established in 54.8% patients of Group I and 40% patients of controlgroup (p<0.05). In Group I, the mean insulin index and HOMA index decreased by 15.4% (p=0.001) and19.2% (p=0.003), respectively. The supplementation of L-Carnitine in standard therapy contributed toa significant decrease in serum creatinine level and an increase in the level of glomerular filtration rate(GFR) in Group I patients (p<0.05). Conclusion: The supplementation of L-Carnitine in the complextherapy of patients with coronary artery disease in combination with prostate adenocarcinoma contributesto a significant decrease in insulin resistance, improves the functional state of kidneys.

Item Type:	Article
Additional Information:	doi: 10.5336/medsci.2019-65452
Uncontrolled Keywords:	Insulin resistance; carnitine; coronary disease; prostatic neoplasms.
Subjects:	Internal diseases
Divisions:	Departments > Department of Internal Medicine 2 and phthisiology
Depositing User:	Анастасия Жигар
Date Deposited:	02 Nov 2020 09:50
Last Modified:	02 Nov 2020 09:50
URI:	http://repo.dma.dp.ua/id/eprint/5909

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