Effect of Cadmium Exposure on Male Fertility

Onul, N.M. and Biletska, E.M. and Holovkova, T.A. and Makarenko, O.V. (2020) Effect of Cadmium Exposure on Male Fertility. Annali D'Italia (№ 5(1)). pp. 17-19. ISSN 3572-2436

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Abstract

Background. Among the xenobiotics of diverse nature, heavy metals are especially dangerous for the human reproductive system in case of excessive intake. Cadmium, which is one of the most common toxic substances for the environment and production, can pose a potential threat to human health. An increasing amount of cadmium in the environmental objects and in nutrition is believed to be related to a poor semen quality. Aim. To determine the impact of cadmium on the reproductive potential of men who live in ecologically contrasting conditions. Materials and methods. Clinical and hygienic assessment of the reproductive health was carried out among 2 experimental groups: 1 group - fertile men living in the city of Dnipro (62 respondents), 2 group - men with normal fertility living in the control city (37 respondents). Results. Cadmium content in the blood and in the sperm of the fertile men of industrial city 1.3-5.8 times higher than the results of research in the control city and literature data. Differences between the cadmium content in the blood and semen of fertile men have been shown to be unlikely, suggesting that the hematotesticular barrier is insufficient to protect the male reproductive organs from the toxic effects of the metal. The ejaculate in the fertile men of the studied cities is characterized by normosospermia and meets the standards. However in the residents of the industrial city the ejaculate quality indices were mostly at the lower level of the norm and were significantly worse than in the residents of the control city. Cadmium contained in male biosubstrates affect the hormonal status and quality of semen. Conclusions. Violations of spermatogenesis can serve as a rapidly-responding and reliable criterion for assessing the adaptation and maladaptation processes of men under the influence of xenobiotics of the environment, in particular cadmium. In this case, the markers of influence are the total number of sperm in the ejaculate, their concentration, mobility and the number of pathological forms, semen viscosity.

Item Type:	Article
Uncontrolled Keywords:	кадмій, вплив, біомоніторинг, фертильність, еякулят. rational nutrition, violation, women, industrial region.
Subjects:	General hygiene
Divisions:	Departments > Department of General Hygiene
Depositing User:	Анастасия Жигар
Date Deposited:	04 Nov 2020 14:14
Last Modified:	03 Dec 2021 13:11
URI:	http://repo.dma.dp.ua/id/eprint/5920

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