Сomorbidity profile in chronicbrain ischemia on the backgroundof multifocal atherosclerosis

Dzyak, L.A. and Rosytska, O.A. (2019) Сomorbidity profile in chronicbrain ischemia on the backgroundof multifocal atherosclerosis. Медичні перспективи, 4. pp. 74-83. ISSN 2307-0404

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Abstract. Comorbidity profile in chronic brain ischemia on the background of multifocal atherosclerosis.Dzyak L.А., Rosytska О.А. Aim to evaluate the comorbidity profile in patients with chronic cerebral ischemia on thebackground of multifocal atherosclerosis. The study included 137 patients aged 40 to 84 years with chronic cerebralischemia (CСI) on the background of multifocal atherosclerosis, which were divided into three clinical groupsdepending on the localization of vascular lesions by stenosing atherosclerosis. The co-morbidity profile and severitywere evaluated using the Charlson’s index in modification of R.A. Deyo (1992). In CCI patients, regardless of thecombination of vascular basins affected by atherosclerosis, a severe degree of comorbidity prevailed - the Charlson’scomorbidity index (IC) was predominantly > 5 points (84.7% of cases). In the analysis of IC in age categories,depending on the combination of atherosclerotic lesions of the vascular basins, it was found that comorbidity of severedegree (IC> 5) was predominantly represented by patients of the older age group (60-74 years), and comorbidity ofmoderate severity (IC≤5) – patients of middle age group (45-59 years). A median difference of 3 points in assessing themean value of age-matched comorbidity index showed that age, as a non-modifiable risk factor, in 1/3 cases determinesthe comorbidity index, which depends on the number of vascular basins affected by atherosclerosis. In 2/3 of the casesit is a modified comorbid pathology. Assessment of IC in clinical groups, taking into account the nature of the diseasecourse (p <0.05), showed a correlation between the number of atherosclerosis affected by vascular basins, the severityof the clinical course of CCI and the severity of comorbidity. The severity of comorbidity, as measured by theCharlson’s index modified by R.A. Deyo, depends on age and determines the nature of the atherosclerotic lesion, aswell as the severity of the clinical course of CCI. Assessing the profile and severity of comorbidity makes it possible toinfluence the nature of the development and course of brain ischemia, which is caused by systemic atheroscleroticlesions of the vascular system.

Item Type: Article
Additional Information: https://doi.org/10.26641/2307-0404.2019.4.189299
Uncontrolled Keywords: хронічна ішемія мозку, фактори ризику, коморбідність, індекс коморбідності Charlson модифікований,chronic brain ischemia, risk factors, comorbidity, Charlson’s comorbidity index modified.
Subjects: Neurological disease
Divisions: Faculty of Postgraduate Education > Department of Family Medicine FPE
Faculty of Postgraduate Education > Department of Neurology and Neurosurgery FPE
Depositing User: Оксана Мажуга
Date Deposited: 18 Nov 2020 09:23
Last Modified: 18 Nov 2020 09:23
URI: http://repo.dma.dp.ua/id/eprint/5956

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