Mathematical modelling in ranking timolol single active ingredient drugs by the efficacy criterion

Sakovych, V.M. and Makarenko, O.V. and Kryvoviaz, O.V. and Tomashevska, Yu.O. and Koval, V.M. (2020) Mathematical modelling in ranking timolol single active ingredient drugs by the efficacy criterion. Офтальмологический журнал = Journal of Ophthalmology (№ 4). pp. 83-88. ISSN 2413-8746 (Russian/Ukrainian ed. Online), 0030-0675 (Russian/Ukrainian ed. Print), 2412-8740 (English ed. Online)

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Abstract

Background: Glaucoma is a disease that is associated with elevated intraocular pressure. Most commonly, single active agent beta-adrenoceptor blockers (particularly, timolol-only preparations) are used as a first-line therapy for primary open-angle glaucoma (POAG). Purpose: To compare the efficacy of various timolol-only preparations available in the Ukrainian pharmaceutical market as a monotherapy for POAG on the basis of expert assessment. Methods: Forty-four ophthalmologists from various Ukrainian regions participated in the questionnaire survey. The participants varied in length of service, academic degree and experience in managing the disease. Survey data were processed using the method of the prior ranking of factors. Results: Mathematic modeling was used to construct the bar chart of ranks from the processed results of the survey. The overall impact of any factor on the examined variable was assessed through the sum of ranks. Conclusion: The method of the prior ranking of factors was used to establish that, in the opinion of the surveyed ophthalmologists, CUSIMOLOL, ARUTIMOL and OFTAN TIMOLOL are the three most efficient timolol-only preparations for the treatment of POAG. The method of the prior ranking of factors was used to establish that, in the opinion of the surveyed ophthalmologists, CUSIMOLOL, ARUTIMOL and OFTAN TIMOLOL are the three most efcient timolol-only preparations for the treatment of POAG.

Item Type:	Article
Uncontrolled Keywords:	a priori ranking, glaucoma, Timolol drugs.
Subjects:	Social medicine, organization and health economics
Divisions:	Departments > Department of Ophthalmology Faculty of Postgraduate Education > Department of social medicine, public health and health care management
Depositing User:	Анастасия Жигар
Date Deposited:	19 Nov 2020 14:23
Last Modified:	25 Jun 2021 08:42
URI:	http://repo.dma.dp.ua/id/eprint/5967

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