Efficiency of neuroprotections at experimental allergic encephalomyelitis on the background of therapy by methylprednisolone

Nefodov, Oleksandr and Frolova, Hanna and Prydius, Iryna and Malchugin, Roman (2020) Efficiency of neuroprotections at experimental allergic encephalomyelitis on the background of therapy by methylprednisolone. Modern Science — Moderní věda, № 3. pp. 121-126. ISSN 2336-498X

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Abstract

A comparative analysis of the neuroprotective effect of Citicoline, Neurovitan and α-lipoic acid on the model of experimental equivalent of multiple sclerosis in rats under baseline hormone therapy with methylprednisolone (Solu-Medrol) was conducted. Experimental allergic encephalomyelitis (EAE) was developed for 9 - 11 days after inoculation of encephalitogenic mixture in 92% of the rats of the control group. Injection of Solu-Medrol (SM, 3.4 mg / kg intravenously over a week) prevented the development of EAE in 20% of animals from infected rodents and significantly reduced the severity and duration of neurological disorders, in 2 - 3 times (compared with control) reducing the average cumulative index and duration of the disease. The animals treated with Citicoline (500 mg / kg) in a course of hormone therapy SM EAE developed only after completion of drug administration (19 - day 20), leaking momentarily (average 5 days) and mild (average cumulative index 6.6). High efficiency of Citicoline with EAE mediated likely to continue internal and external (cytoplasmic and mitochondrial) neuronal membranes due, on the one hand, the weakening of the activity of phospholipase A2 activation and neuronal mitochondrial cytochrome oxidase, and the other - the inhibition of glutamateinduced apoptosis

Item Type:	Article
Uncontrolled Keywords:	multiple sclerosis, experimental allergic encephalomyelitis, methylprednisolone, neuroprotection, Citicoline, Berlitione, Neurovitan.
Subjects:	Pharmacology Physiology Anatomy Experimental medicine
Divisions:	Departments > Department of General and Clinical Pharmacy Departments > Department of human anatomy, clinical anatomy and operative surgery
Depositing User:	Елена Шрамко
Date Deposited:	26 Nov 2020 09:54
Last Modified:	26 Nov 2020 09:54
URI:	http://repo.dma.dp.ua/id/eprint/6004

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