Experimental determination of the influence of cadmium salt on cardiogenesis of a rat

Nefedova, Olena and Galperin, Oleksander and Filippov, Yuri (2020) Experimental determination of the influence of cadmium salt on cardiogenesis of a rat. Modern Science — Moderní věda, № 2. pp. 101-110. ISSN 2336-498X

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The results of an experimental effect on the cardiogenesis of intragastric administration of cadmium chloride / cadmium citrate to pregnant female rats are discussed in the article. Except for groups of isolated cadmium salts administration, there were groups of combined administration of cadmium with citrates of germanium, cerium and composite iodine + sulfur. The second task was to study the effect of the studied salt solutions on the cardiogenesis of rat embryos, for which serial histological sections of the heart were made and the thickness of the chambers of the heart and interventricular septum were measured. The thickness of the compact myocardium of the heart chambers was measured as the main indicator of cardiogenesis. The effect of the indicated doses of cadmium salts on cardiogenesis in rats influenced differently on the thickness of the myocardial layer of various chambers of the heart: cadmium chloride thickened the wall of the left and right ventricle, both atriums with thickening of the interventricular septum. Cadmium citrate provokes thinning of the myocardium of the walls of both ventricles and local thickening of the interventricular septum. In the groups of combined administration, indicators of the thickness of the compact myocardium recovered, which indicates the modifying effect of citrates of the studied microelements on the cardiotoxicity of cadmium salts.

Item Type: Article
Uncontrolled Keywords: rat embryo, cardiogenesis, cadmium, metal citrate, heart
Subjects: Anatomy
Experimental medicine
Divisions: Departments > Department of human anatomy, clinical anatomy and operative surgery
Depositing User: Елена Шрамко
Date Deposited: 26 Nov 2020 13:39
Last Modified: 26 Nov 2020 13:39
URI: http://repo.dma.dp.ua/id/eprint/6008

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