The concentration of ceruloplasmin in blood of tumor-bearing rats after administration of a dirhenium (III) compound and cisplatin

Hrabovska, O.I. and Shamelashvili, K.L. and Shtemenko, O.V. and Shtemenko, N.I. (2019) The concentration of ceruloplasmin in blood of tumor-bearing rats after administration of a dirhenium (III) compound and cisplatin. The Ukrainian Biochemical Journal=Український біохімічний журнал, V. 91 (№ 6). pp. 79-85. ISSN 2413-5003 (Online), 2409-4943 (Print)

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Abstract

Contemporary investigations of mechanisms of resistance to platinides showed the key role of copper metabolism in cancer patients and proposed possible methods to attenuate the resistance by modulation of copper transporting mechanisms. In this vein, investigation of ceruloplasmin (Cp) levels – the main copper-containing protein in blood, in experiments with tumor-containing animals upon cytostatics administration is topical and has great importance. the concentration of Cp was measured in the serum of tumor-bearing rats with ordinary (Т8) and resistant to cisplatin (Т8*) Guerin’s carcinoma upon administration of cisplatin and quadruple bonding dirhenium(III) compound dichlorotetra-μ-isobutyratodirhenium(ІІІ) (I) in different medicamental forms. It was shown that development of tumor in t8 group led to increasing of concentration of Cp in 3.7 times and in T8* group – more than in 8 times in comparison to control, confirming the essential role of Cp in the formation of resistance phenomenon. Administration of cisplatin with I led to effective inhibition of tumor in groups with T8 and T8*, indicating decreased resistance in the group T8*. Creater reduction of Cp levels was observed in the groups with T8* upon administration of the rhenium-platinum antitumor system, than in gruops with T8, that underlines the importance of further investigations of the dirhenium (III) compounds in the resistance to cytostatics cancer models.Some mechanisms concerning the regulation of copper homeostasis and properties of nano-composites are discussed.

Item Type:	Article
Additional Information:	https://doi.org/10.15407/ubj91.06.079
Uncontrolled Keywords:	ceruloplasmin, cluster rhenium(III) compound, Guerin’s carcinoma, resistance to cisplatin.
Subjects:	Medical Biology
Divisions:	Departments > Department of Medical Biology, Botany and Pharmacognosy
Depositing User:	Анастасия Жигар
Date Deposited:	01 Dec 2020 08:19
Last Modified:	01 Dec 2020 14:36
URI:	http://repo.dma.dp.ua/id/eprint/6026

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