Роль генетических исследований в диагностике заболеваний височно-нижнечелюстного сустава

Семенов, К.А. and Деньга, О.В. and Горохивский, В.Н. (2018) Роль генетических исследований в диагностике заболеваний височно-нижнечелюстного сустава. Клінічна хірургія (№ 5). pp. 51-54. ISSN 0023-2130 (Print), 2522-1396 (Online)

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Abstract

На основании генетического исследования по определенному набору генетических маркеров и их анализу уточнены и подтверждены клинические диагнозы. Определенный набор генетических маркеров и их цифровое значения позволяют составить прогноз течения патологического процесса и на основании этого проводить лечебные и профилактические мероприятия, разработать индивидуальный протокол лечения пациентов с заболеваниями ВНЧС. Objective. In accordance to the genetic investigation results and their numerical value to confirm clinical diagnoses in patients for further adjustment of the treatment–prophylactic plan.Маterials and methods. In the investigation 10 patients took part: 5 women and 5 men, ageing 25 – 50 yrs old. Analysis was conducted in laboratory of molecular– genetic investigations – Ltd «Germedtech», City of Odessa. The Dellaport’s method was applied for isolation and purification of deoxyribonucleic acid from buccal cells.Results. Basing on results of the genes GSTM1, CoL2A1, MMP1, ER, IL1B, TNF analysis, taking part in metabolism of the joint os-teo–cartilaginous tissue, a genetic risk of the diseases of the temporo–mandibular joint development was determined.Conclusion. Basing ongenetic investigation, concerning certain quantity of genetic markers and their analysis, clinical diag-noses were clarified and confirmed. Certain quantity of genetic markers and their numerical values permit to prognosticate the pathological process course, to conduct treatment and prophylactic measures and to elaborate individual protocol of treatment on this background in patients, suffering diseases of temporo–mandibular joint.

Item Type:	Article
Additional Information:	https://doi.org/10.26779/2522 -1396.2018.05.51
Uncontrolled Keywords:	заболевания височно–нижнечелюстного сустава; пациенты; результаты генетического исследования. diseases of temporo–mandibular joint; patients; results of genetic investigation.
Subjects:	Maxillofacial Surgery
Divisions:	Faculty of Postgraduate Education > Department of Dentistry FPE
Depositing User:	Анастасия Жигар
Date Deposited:	14 Apr 2021 08:07
Last Modified:	14 Apr 2021 08:07
URI:	http://repo.dma.dp.ua/id/eprint/6445

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