Kharaponova, EB. and Drozdov, A.L. and Silkina, Yu.V. (2015) Structural and functional changes of mitochondria in rat cardiomyocytes in subacute administration of sydnocarb. European journal of biomedical and life sciences, № 3. pp. 97-100.
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Abstract
We described three types of mitochondria, differing in shape, size and density of cristae. During subacute administration, sydnocarb has cardiotoxic effect in form of degradation of mitochondria and mitochondrial cristae. Due to sydnocarb-induced vasodilatation and swelling of cardiomyocytes, the most sensitive to hypoxia were type-1 mitochondria. It was reported not only about destruction of cristae, but also mitochondrial degradation in some areas of cardiomyocytes. The least sensitive to increasing hypoxia were type-3 mitochondria.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | mitochondrion, cardiomyocyte, sydnocarb, cardiotoxic effect. |
| Subjects: | Pathological physiology Experimental medicine |
| Divisions: | Departments > Department of Pathological Physiology |
| Depositing User: | Анастасия Жигар |
| Date Deposited: | 12 Apr 2016 08:24 |
| Last Modified: | 12 Apr 2016 08:24 |
| URI: | http://repo.dma.dp.ua/id/eprint/685 |
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