Myelodysplastic syndrome on the background of severe hypothyroidism: case report

Khaniukov, O.O. and Pesotskaya, L.A. and Korolenko, H.S. and Kravchenko, O.I. and Shchukina, O.S. (2021) Myelodysplastic syndrome on the background of severe hypothyroidism: case report. In: International scientific innovations in human life. Proceedings of the 2nd International scientific and practical conference. Cognum Publishing House, Manchester, United Kingdom, pp. 20-32. ISBN 978-92-9472-195-2

Text INTERNATIONAL-SCIENTIFIC-INNOVATIONS-IN-HUMAN-LIFE-25-27.08.21_P. 20-32.pdf Download (567kB)

Abstract

Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal diseases of the blood system arising from mutation of the hematopoietic stem cell and characterized by cytopenia as a result of ineffective hematopoiesis, signs of dysmyelopoiesis and a high risk of transformation into acute leukemia. More than 80% of patients with MDS are over 60 years old. About 25 thousand new cases are diagnosed annually in Europe. Given the steady aging of the European population, it is believed that the number of patients with MDS will only increase in the coming decades. In addition, signs of myelodysplasia can be detected in the bone marrow or peripheral blood, not only in MDS, but also in other non-clonal diseases. The role of thyroid hormones in hematopoiesis is known, which does not exclude the development of dysmyelopoiesis in hypothyroidism. The article presents the classification, clinical manifestations of primary MDS and a clinical case of the development of the disease against the background of severe hypothyroidism with features of the course of MDS.

Item Type:	Book Section
Additional Information:	URL: https://sci-conf.com.ua/ii-mezhdunarodnaya-nauchno-prakticheskaya-konferentsiya-international-scientific-innovations-in-human-life-25-27-avgusta-2021-goda-manchester-velikobritaniya-arhiv/
Uncontrolled Keywords:	myelodysplastic syndrome, single-line dysplasia, severe hypothyroidism
Subjects:	Internal Medicine Morphology
Divisions:	Departments > Department of Internal Medicine 3 (formerly - hospital therapy 2) Departments > Department of Pathological Anatomy and Forensic Medicine
Depositing User:	Елена Шрамко
Date Deposited:	22 Sep 2021 07:46
Last Modified:	22 Sep 2021 07:46
URI:	http://repo.dma.dp.ua/id/eprint/6935

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