Evaluation of bone resorptive potential in the treatment of generalized periodontitis

Fastovets, Olena O. and Masheiko, Ivan V. and Lucash, Anna Y. (2020) Evaluation of bone resorptive potential in the treatment of generalized periodontitis. Wiadomości Lekarskie = Medical News, 73 (11). pp. 2396-2402. ISSN 0043-5147

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The aim: Is to study dynamics of resorptive potential of bone tissue by indicators of protease and antiprotease systems in the process of treatment generalized periodontitis in patients with age-related osteoporosis and without osteoporotic changes in the skeleton. Materials and methods: In 102 patients, before the start of treatment of generalized periodontitis and in 2, 4 and 12 weeks, the concentration of pro-resorbing matrix metalloproteinases: stromelysin (MMP-3), collagenase (MMP-8) and gelatinase (MMP-9) were determined in blood plasma and mixed oral fluid. The antiresorbtive potential of bone tissue was evaluated by the concentration of a tissue inhibitor of metalloproteinases (TIMP-1) in plasma. The general antiprotease activity was determined by the activity of α1-antitrypsin (α1-AT) and α2-macroglobulin (α2-MG). Results: The most significant changes are recorded for the content of MMP-9 in blood and oral fluid, regardless of the presence of systemic disorders of bone metabolism (P < 0.05). Concentration of MMP-8 is significantly increased in blood plasma and oral fluid in accordance with the severity of the disease and in the course of treatment (P <0.05). The observed increase in the ratio of MMP-8 to TIMP-1 and MMP-9 to TIMP-1 in patients with generalized periodontitis, complicated by systemic osteoporosis (P < 0.05), indicates an imbalance of the protease-antiprotease system. Conclusions: The resorptive potential of bone tissue in patients with generalized periodontitis allows us to correctly choose treatment tactics and to prevent the development of complications.

Item Type: Article
Subjects: Therapeutic dentistry
Divisions: Departments > Department of Orthopedic Dentistry
Depositing User: Елена Шрамко
Date Deposited: 27 Oct 2021 13:22
Last Modified: 27 Oct 2021 13:22
URI: http://repo.dma.dp.ua/id/eprint/7030

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