The principle of combined preoperative diagnosis of thyroid tumors

Zalyubovska, Olga I. and Hladkykh, Nadiia O. and Gritsenko, Petro O. (2021) The principle of combined preoperative diagnosis of thyroid tumors. Wiadomości Lekarskie = Medical News, 74 (3 p. 1). pp. 529-534. ISSN 0043-5147

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Abstract

The aim of the research is to increase the effectiveness of preoperative diagnosis of patients with thyroid tumors and to assess the use of cancer-embryonic antigen and immunocytochemical research. Materials and methods: Patients were interviewed about their complaints and lifestyle; performed ultrasound with fine-needle aspiration, determination of the level of cancer-embryonic antigen (CEA), cytological and immunocytochemical researches. Results: The Benign process in the thyroid gland is low serum REA (less than 0.95 ng / ml), poor expression of thyroglobulin (77.8%), negative reaction with TTF-1 (100%) and cytokeratin-19 (55.6%). Differential-prognostic markers of thyroid neoplasms with risk of malignancy include increased serum REA (0.95 ng / ml and above), the presence of a moderate reaction with antibodies to thyroglobulin (80.0%), a positive reaction — to TTF-1 (100.0%) and E-cadherin (90.0%), with moderate or strong expression of cytokeratin-19 (90.0%). Statistically significant markers of malignant thyroid disease were determined: the presence of harmful factors at work (45.5%), smoking (27.3%), elevated serum REA (0.95 ng / ml and above), the presence of strong cytoplasmic expression of thyroglobulin (63.6%), moderate or strong expression of TTF-1 (90.9%) and cytokeratin-19 (81.8%). Conclusions: The most appropriate and practically significant for preoperative diagnosis of thyroid tumors is a set of several diagnostic methods, which are carried out in one hospital – ultrasound with fine-needle aspiration, cytomorphological, and immunocytochemical and REA levels in a primary screening.

Item Type:	Article
Additional Information:	DOI: 10.36740/WLek202103127
Uncontrolled Keywords:	thyroid gland, nodular diseases of the thyroid gland, carcinoma, diagnosis, fine-needle aspiration puncture biopsy
Subjects:	Pathological anatomy
Divisions:	Departments > Department of Pathological Anatomy and Forensic Medicine
Depositing User:	Елена Шрамко
Date Deposited:	17 Nov 2021 08:54
Last Modified:	17 Nov 2021 08:55
URI:	http://repo.dma.dp.ua/id/eprint/7125

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