Efficiency of using recombinant morphogenentic protein in patients with aggressive (rapidly-progressing) generalized periodontis

Gudaryan, Alexandr and Kucherenko, Taras (2021) Efficiency of using recombinant morphogenentic protein in patients with aggressive (rapidly-progressing) generalized periodontis. Modern Science — Moderní věda (№ 1). pp. 122-129. ISSN 2336-498X

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Abstract

Annotation. Currently, the inclusion in the complex therapy of generalized periodontitis of drugs that significantly affect the processes of physiological remodeling and bone regeneration is becoming more common. Given the relevance of the search for drugs to restore periodontal bone structures, the aim of our study was to increase the effectiveness of standard therapy for aggressive (rapidly progressing) generalized periodontitis by additionally incorporating the morphogenetic bone protein rhbmp-2 into the generally accepted treatment complex. We observed a contingent of patients in the amount of 61 people, with a diagnosis of aggressive (rapidly progressing) generalized periodontitis, which were divided into the main - 30 people, and the comparison group - 31 people. we used standard clinical, paraclinical and laboratory research methods, supplemented by dental volumetric tomography. In the main group, patients in addition to the standard treatment regimen (comparison group) included the recombinant morphogenetic protein rhbmp-2. The results of a clinical examination conducted after 6-12 months revealed the absence of inflammatory phenomena in periodontium in 90% of the main group, and only 77.4% of patients in the comparison group. Measurements of bone density on the hounsfield scale (hu) in the same period showed a 2-fold increase in the density of periodontal bone structures, with a comparison group. it follows that the inclusion in the standard regimen of complex treatment for patients with rapidly progressing generalized periodontitis of the osteoinductive drug rhbmp-2 allows for longterm clinical and radiological remission, and creates conditions for the subsequent restoration of the density of periodontal bone structures.

Item Type:	Article
Uncontrolled Keywords:	Periodontitis, Aggressive (Rapidly Progressive) Periodontitis, Rhbmp-2, Recombinant Morphogenetic Protein, Physiological Bone Remodeling, Bone Tissue Regeneration, Treatment Of Periodontitis.
Subjects:	General dentistry
Divisions:	Departments > Department of Operative Dentistry, Periodontology and Implantology
Depositing User:	Елена Шрамко
Date Deposited:	09 Dec 2021 16:57
Last Modified:	09 Dec 2021 16:57
URI:	http://repo.dma.dp.ua/id/eprint/7195

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