Effects of strontium ranelate on alveolar bone in rats with experimental diabetes mellitus

Matvieienko, L.M. and Matvieienko, R.Y. and Fastovets, O.O. (2022) Effects of strontium ranelate on alveolar bone in rats with experimental diabetes mellitus. Wiadomości Lekarskie = Medical News, 75 (1 p.2). pp. 151-155. ISSN 0043-5147

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Abstract

The aim: To investigate effects of strontium ranelate on alveolar bone loss in rats with experimental diabetes. Materials and methods: Histological examination of bone tissue was carried out for 24 white male rats, divided into three identical groups of 8 animals (the first group included animals with experimental type-2 diabetes, based on the use of Streptozotocin; in the second group, it was additionally reproduced periodontitis by the introduction of Penicillamine; and in the third group, in addition, it was used strontium ranelate) and 6 intact rats. Results: In the second group, osteoporosis phenomena were most significant, while in the third group the average specific area of the inter-root trabecular bone differed a little from the control. In the control group, the number of osteoclasts was 2.24 ± 1.41 cells per mm2 , in the first group – 4.34 ± 1.37 cells per mm2 , in the second group – 2.96 ± 1.26 cells per mm2 and in the third group – 2.24 ± 1.41 cells per mm2 (p>0.05). The samples of the third group have the most expressive manifestations of osteogenesis and the most intense expression of osteopontin, both in trabecular and compact bone tissue. Conclusions: The use of strontium drugs reliably slows down the processes of bone resorption due to both inhibition of the function of osteoclasts, and by activating osteoblasts, thus stimulating osteogenesis.

Item Type:	Article
Additional Information:	https://www.scopus.com/record/display.uri?eid=2-s2.0-85124933367&origin=resultslist&sort=plfdt-f&listId=57430343&listTypeValue=Docs&src=s&imp=t&sid=f801ea59680576a88aa9769f7b37171a&sot=sl&sdt=sl&sl=0&relpos=1&citeCnt=0&searchTerm=&featureToggles=FEATURE_NEW_DOC_DETAILS_EXPORT:1
Uncontrolled Keywords:	osteoblasts, osteoclasts, osteopontin, periodontitis, treatment
Subjects:	Experimental medicine
Divisions:	Departments > Department of Orthopedic Dentistry Departments > Department of Therapeutic Stomatology
Depositing User:	Елена Шрамко
Date Deposited:	16 Mar 2022 10:06
Last Modified:	16 Mar 2022 10:08
URI:	http://repo.dma.dp.ua/id/eprint/7388

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